Synthesis; Characterization and Anti Inflammatory Activity of “3-(2-[1H Benzimidazole-2-YL)-2-Oxethyl] Phenyl) Acetic Acid and Its Derivatives”

Abstract

A series of five-membered heterocyclic rings like Benzimidazole were synthesized by the reaction between benzene-1, 2 diamine and formic acid to form various Benzimidazole derivatives (BD- BK) compounds and was tested for their anti-inflammatory activity determined by rat-paw- oedema method. All the synthesis compounds have been characterized by 1HNMR, IR and some Mass spectral data. The compounds were purified by recrystallization method. The entire compound gives good response for the anti-inflammatory activity: Benzimidazole (AA), 1-(1H-benzimidazol-2-yl)-2-(3-hydroxyphenyl) ethanone (AC); 2-{3-[2-(1H-benzimidazol-2-yl)-2-oxoethyl] phenyl}-N-phenylacetamide (AJ); 2-{3-[2-(1H-benzimidazol-2-yl)-2-oxoethyl] phenyl}-N-(2-nitrophenyl) acetamide (AK); 2-{3-[2-(1H-benzimidazol-2-yl)-2-oxoethyl] phenyl}-N-(3-nitrophenyl) acetamide (AL). For this anti-inflammatory activity, Indometacin was used as a standard drug and compared to new synthesized drugs. Some new synthesized drugs have shown better activities for the anti-inflammation. The synthesize compounds were establish to be AA to AL. The compound AA, AC, AJ, AK and AL were established to be the most potent compound through compare to standard drugs Indomethacin.