Dental Fluorosis: Dilemma of Genetic Susceptibility
Luay Thanoon Younis, Faatin Afeefah Ahmad Naqiyuddin, Afiqah Azhar, Ahmad Izzat Arief Amron, Aida Nur Ashikin Abd Rahman, Mohamed Ibrahim Abu Hassan
Asian Journal of Dental Sciences · pp. 21–26 · Published 25 Mar 2020
Abstract
Excessive exposure to fluoride during formation of teeth may lead to a severe hypomineralization condition, called dental fluorosis. Genes such as Collagen type 1 alpha 2 (COL1A2), Estrogen receptor (ESR), Prolactin (PRL), Catechol-o-methyltransferase (COMT), matrix metalloproteinase 20 (MMP20) and many others have been implicated in the incidence of dental fluorosis. This mini-review is an insight into the fact that fluorosis incidence and intensity are significantly related to individual’s genetic background.
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