Association between Leptin and Lipid Profile among Women

Abstract

Aim: The present study was aimed to assess the association between leptin and lipid profile among non-obese and obese women subjects. Method: 60 non-obese and 60 obese women working in various educational institutes and hospitals in the age group of 30-60 years were selected. Their body measurement like height and weight were taken with standardized methods and BMIs were calculated as per World Health Organization guidelines. After ensuring fasting for 12 hours, blood sample of 5 ml was collected in sterile tubes from anti-cubital vein under aseptic conditions. Blood samples were allowed to stand and then centrifuged immediately at room temperature. Serum was separated, aliquots were made and samples were stored in freezer at -20o C for further analysis. Lipid profile and leptin levels were assessed as per protocols mentioned in the kits. Result: Dyslipidemia coupled with hyperleptimia was observed among the obese subjects as compared to their non-obese counterparts. Correlation was observed among different components of lipid profile and leptin and this association was stronger in the obese subjects. Conclusion: Hyperleptimia and dyslipidemia might be playing role in obesity. It is difficult to say if higher leptin levels leads to worsen the lipid profile or vice versa. Efforts to normalize lipid profile may lead to lower leptin levels and check obesity.