Shared Allergenicity in a Lapin-Model of Delayed Htpersensitivity to Gram Negative Protoplasmic Sonicate Proteins PSP

Abstract

There were shared allergenicity in delayed type hypersensitivity between the protoplasmic sonicate proteins of Pseudomonas aeruginosa with that of Klebsiella oxytoca Mild erythema was noted from 6 to72 hrs post to P. aeruginosa (PSP) in Klebsiella oxytoca PSP primed rabbits (KOPSP). Mild, moderate to high erythema during 6 up to 72 hrs post to injecting KOPSP in PAPSP primed rabbits. Induration of 5 mm at 72 hrs of PAPSP intradermal ID injecting in KOPSP primed rabbits. While induration of 6 to 12 mm of KOPSP ID injected to PAPSP primed rabbits. Consenquently there was a high quantitative and /or potency of the allergenic fraction of KO than that of PA. The shared fractions were characterized as delayed allergenicity of bilateral or reciprocal type delayed allergenic nature. Such findings appeared to be novel contribution in bacterial protein allergens, with possible pan shared bacterial families. Preserved protein fraction between these two different gram negative representatives of bacterial families.