An Unusual Case of Idiopathic Noncirrhotic Portal Hypertension Complicated by Hepatic Encephalopathy and Hepatocellular Carcinoma
Ahmed Lutful Moben, Rokshana Begum, Sheikh Mohammad Noor E Alam, Md. Abdur Rahim, Bishnu Pada Dey, Musarrat Mahtab, Sheikh Mohammad Fazle Akbar, Mamun Al Mahtab
Asian Journal of Research and Reports in Hepatology · pp. 121–129 · Published 9 Dec 2025
10.9734/ajrrhe/2025/v7i157Abstract
Idiopathic Noncirrhotic Portal Hypertension (INCPH) is a rare disease entity which is characterized by intrahepatic portal hypertension in the absence of cirrhosis and other liver diseases and splanchnic venous thrombosis. Etiology of INCPH remains unknown and immunological disorders, chronic infections, exposure to medicines and toxins, genetic disorders and prothrombotic conditions have been implicated with the development of INCPH. The diagnosis is by exclusion and depends on clinical and histopathological features. Here we present a case of INCPH with rather unusual clinical course from Bangladesh. This young female presented with repeated bouts of hematemesis and melaena. She had features resembling decompensated liver cirrhosis and eventually developed hepatic encephalopathy and hepatocellular carcinoma.
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