Type 2 Autoimmune Hepatitis Triggered by  Hepatitis A Virus: A Case Report

Ghita Hachim; Abdelhakim Ourrai; Abdelilah Radi; Najat Lamalmi; Rachid Abilkassem; Rihane El Mohtarim; Amal Hassani; Aomar Agadr

doi:10.9734/ajpr/2022/v9i230264

Research Article Open access CC BY 4.0

Type 2 Autoimmune Hepatitis Triggered by Hepatitis A Virus: A Case Report

Ghita Hachim, Abdelhakim Ourrai, Abdelilah Radi, Najat Lamalmi, Rachid Abilkassem, Rihane El Mohtarim, Amal Hassani, Aomar Agadr

Asian Journal of Pediatric Research · pp. 21–25 · Published 6 Aug 2022

10.9734/ajpr/2022/v9i230264

Abstract

Autoimmune Hepatitis (AIH) pathogenesis is still unknown. However, among patients who have a genetic susceptibility, some viral infections appear to be triggers for AIH. We report a case of a child who developed type 2 autoimmune hepatitis as a result of HEPATITIS A Virus (HAV) infection. An 8-year-old female who was diagnosed with hepatitis A three years ago and was cured after three months. She developed jaundice and epistaxis a few years later. Complementary tests revealed polyclonal hypergammaglobulinemia, antinuclear and anti-LC1 antibodies, and hepatocyte necrotico-inflammatory lesions in a liver biopsy. The diagnosis of type 2 autoimmune hepatitis was kept. A remission was obtained under corticosteroid and azathioprine treatment. In cases of persistent HAV infection, AIH should be investigated so that therapy can start earlier. To prevent more serious complications, AIH patients should also receive the Hepatitis B Virus (HBV) and HAV vaccines.

Autoimmune hepatitis hepatitis A antibodies

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Ghita Hachim, Abdelhakim Ourrai, Abdelilah Radi, Najat Lamalmi, Rachid Abilkassem, Rihane El Mohtarim, Amal Hassani, Aomar Agadr (2022). Type 2 Autoimmune Hepatitis Triggered by Hepatitis A Virus: A Case Report. Asian Journal of Pediatric Research , 21–25. https://doi.org/10.9734/ajpr/2022/v9i230264

Affiliations

Ghita Hachim — Department of Pediatrics, Mohammed V Military Instruction Hospital, Rabat, Morocco.
Abdelhakim Ourrai — Department of Pediatrics, Mohammed V Military Instruction Hospital, Rabat, Morocco.
Abdelilah Radi — Department of Pediatrics, Mohammed V Military Instruction Hospital, Rabat, Morocco.
Najat Lamalmi — Department of Pediatrics, Mohammed V Military Instruction Hospital, Rabat, Morocco.
Rachid Abilkassem — Department of Pediatrics, Mohammed V Military Instruction Hospital, Rabat, Morocco.
Rihane El Mohtarim — Department of Pediatrics, Mohammed V Military Instruction Hospital, Rabat, Morocco.
Amal Hassani — Department of Pediatrics, Mohammed V Military Instruction Hospital, Rabat, Morocco.
Aomar Agadr — Department of Pediatrics, Mohammed V Military Instruction Hospital, Rabat, Morocco.

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