Inhibin B Levels in Relation to Obesity Measures and Lipids in Males with Different Numbers of Metabolic Syndrome Components
D. O. Laniyan, M. A. Charles-Davies, A. A. Fasanmade, J. A. Olaniyi, O. E. Oyewole, M. O. Owolabi, J. R. Adebusuyi, O. Hassan, B. M. Ajobo, M. O. Ebesunun, K. Adigun, K. S. Akinlade, S. U. Okoli, O. G. Arinola, E. O. Agbedana
Journal of Scientific Research and Reports · pp. 1–12 · Published 30 Mar 2016
10.9734/JSRR/2016/24641Abstract
Introduction: Defective spermatogenesis and metabolic syndrome affect 2-4% and 12.4% of males respectively. Deficient testosterone levels due to increased conversion of testosterone to oestradiol have been demonstrated in males with the metabolic syndrome (MS) with limited pituitary and leptin contribution. Defective spermatogenesis is thus implicated in males with MS but is controversial. Inhibin B is a marker of spermatogenesis. This study aims at evaluating inhibin B levels and their relationship with obesity measures and lipids in males with different number of MS components. Materials and Methods: This is a preliminary prospective study in which a total of 106 apparently healthy males (30, 30, 30 and 16 males with 0, 1, 2 and ≥3 components of metabolic syndrome (NMSC) respectively) aged 19-64 years were purposely selected. Blood pressure (BP) and obesity measures (including visceral adiposity index (VAI) and body mass index (BMI)) were obtained by standard methods. Fasting plasma glucose (FPG), total cholesterol (TC), triglycerides and high density lipoprotein cholesterol (HDLC) were determined by enzymatic methods while low density lipoprotein cholesterol (LDLC) and the lipid ratios (TG/HDLC, TC/HDLC, LDLC/HDLC) were calculated. Inhibin B was analysed by enzyme linked immunosorbent assay (RayBiotech, Inc. USA). Data analysed using analysis of variance (ANOVA) and multiple regressions were significant at P <.05. Results: Inhibin B decreased significantly in males with 0 to 2 NMSC (P <.05). However, inhibin levels between males with 0 and ≥3 NMSC were similar. Age and inhibin B levels were also similar among the different classes of BMI (P>0.05). Inhibin B related positively with HDLC and TC but negatively with VAI, LDLC and TC/HDLC. Conclusion: Reproductive function appears protected in Nigerian males with MS. However, improvement in HDLC, LDLC, TC levels, VAI and TC/HDLC may enhance fertility potential especially in males with one or two MS components, probably through dietary modulation and physical activity.
Cited by 1
Muhammad Faheem Akhtar, Muhammad Umar, Ejaz Ahmad · Veterinary Sciences · 2025
Related research
- Metabolic Syndrome among Healthcare Workers in a Tertiary Hospital in South-South, Nigeria — shares topic coverage
- Cortisol and Metabolic Syndrome Components in Obese and Overweight Young Adults of a Nigerian Private University — shares topic coverage
- Metabolic Syndrome and Kidney Damage: Prevalence and Assessment of Risk among Apparently Healthy Resident of Ado Ekiti, South West Nigeria — shares topic coverage
- Vitamin D and Insulin Resistance in Metabolic Syndrome — shares topic coverage
- Metabolic Syndrome and Its Association with Nutritional and Cardiometabolic Risk Factors: Prevalence among Apparently Healthy Adults in a Rural Community in Southwestern Nigeria — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
1
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.