Cefixime Induced Cutaneous Hypersensitivity Vasculitis: A Rare Case Report

Abstract

Cutaneous hypersensitivity vasculitis (CHV) is a small-vessel inflammatory condition often triggered by medications. Although antibiotics are common culprits, Cefixime, a third-generation cephalosporin, is rarely associated with CHV. This case report is of a 46-year-old male who developed multiple, palpable, purpuric lesions over both lower extremities following a short course of Cefixime. Clinical examination and laboratory results with inflammatory markers and normal differential counts were suggestive of cutaneous vasculitis. Hence, the patient was treated with systemic corticosteroids and supportive care. The lesions gradually resolved with the treatment. Therefore, this case highlights the need for clinician awareness regarding rare but significant cutaneous adverse reactions to Cefixime and other cephalosporins, careful antibiotic selection, and timely management to ensure desired improvement in patients’ condition. It also represents the pharmacovigilance value of reporting unusual adverse drug reactions.