Evaluation of the Effect of Crude Extract and Aqueous Fraction of Acacia nilotica Leaves on Haematological Indices and Serum Electrolytes Levels on Diabetic Wistar Rats
Y. Tanko, R. A. Ibrahim, A. Muhammad, E. D. Eze, A. Jimoh, K. A. Mohammed, A. Mohammed
Journal of Advances in Biology & Biotechnology · pp. 1–7 · Published 30 Jun 2015
10.9734/JABB/2015/18350Abstract
The aim of this study was to evaluate the effect of crude and aqueous fraction of Acacia nilotica on diabetic Wistar Rats. Alloxan at a dose of 150 mg/kg body weight was administered to the rats intraperitoneally to induce diabetes. Thirty rats divided into six groups of five animals (n = 5) each were used for the experiment: Group 1 served as normal control group, Group 2 administered insulin (6 I.U/kg),Group 3 administered 500 mg/kg of crude extract. Group 4 administered 1000 mg/kg crude extract, Group 5 administered 500 mg/kg aqueous fraction and Group 6 received 1000 mg/kg aqueous fraction of Acacia nilotica. There was no significant change in the haematological indices, serum urea, creatinine and potassium compared to control. However, there was a significant increase (p<0.05) in the serum sodium and chloride levels when compared to control. The result indicated that the crude and aqueous fraction of A. nilotica has no effect on haematological indices, urea, creatinine, potassium. However, the fraction has effect on serum sodium and chloride levels on diabetic rats.
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