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Research Article Open access CC BY 4.0

When Oxygen Can Be Toxic? A Mini Review

Ali Mohamed Elshafei

Journal of Applied Life Sciences International · pp. 1–9 · Published 1 Aug 2020

10.9734/jalsi/2020/v23i730171

Abstract

No one within the past later a long time had in intellect that the oxygen we breathe that contributes to sparing the lives of millions of patients and the most component of life has no harmful impacts on the body. Oxygen and water are the soul of living beings in common but beneath certain    conditions such as weak immune status and lack of the body's ability to excrete natural   antioxidants happens that the oxygen atom responds as a receptor for electrons, since its structure within the case of electronic soundness has two electrons that are not bound and as a result of progressive responses that create a few intermediate compounds. (Such as hydroxyl radical    (•OH), hydrogen peroxide (H2O2) and superoxide anion (•O-2) that are hurtful to human’ organs     and influence the extraordinary degree of cell division process and the physiological activities       that it performs since it could be a capable oxidizer. These reactive atoms and free radicals    inferred from atomic oxygen are called Reactive Oxygen Species (ROS). In spite of the fact that ROS play a key part as a flag-bearer in ordinary cell flag transduction and cell cycling, they have long been known to be a component of the immune reaction of safe cells to microbial invasion. ROS are created as byproducts during the mitochondrial electron transport of aerobic respiration or by oxido/reductase proteins and metal-catalyzed oxidation. The primary step in ROS generation is the reduction of atomic oxygen (O2) to anion superoxide (•O-2), is the antecedent of other responsive species. For this reason, the significance of normal cancer prevention agents has gotten to be vital to urge freed of the poisonous quality of ROS and particular antioxidant supplement ought to be given to improve the diet. Among the well-known antioxidants and cancer prevention agents are glutathione, vitamins C and D as well as enzymes such as, superoxide dismutase, catalase and peroxidase which contribute successfully to the disposal of these oxidizing substances.

Interaction of oxygen reactive oxygen species (ROS) oxidative damage anti-oxidative defense.

References (33)

  1. 1 Mitochondrial formation of reactive oxygen species [DOI]
  2. 2 Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships [DOI]
  3. 3 Free radicals and antioxidants in human health: current status and future prospects.
  4. 4 The Haber–Weiss reaction and mechanisms of toxicity [DOI]
  5. 5 Hydrogen peroxide- and glutathione-associated mechanisms of acclimatory stress tolerance and signalling [DOI]
  6. 6 Phenolic compounds and their antioxidant activity in plants growing under heavy metal stress
  7. 7 HEAVY METAL–INDUCED OXIDATIVE STRESS IN ALGAE1 [DOI]
  8. 8 Catalase function in plants: a focus on Arabidopsis mutants as stress-mimic models [DOI]
  9. 9 Regulation of the Arabidopsis Transcriptome by Oxidative Stress [DOI]
  10. 10 Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers [DOI]
  11. 11 TNF-α Is a Predictor of Insulin Resistance in Human Pregnancy [DOI]
  12. 12 Drought Induces Oxidative Stress and Enhances the Activities of Antioxidant Enzymes in Growing Rice Seedlings [DOI]
  13. 13 Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space [DOI]
  14. 14 Mitochondrial function in normal and diabetic β-cells [DOI]
  15. 15 The glutathione system as a stress marker in plant ecophysiology: is a stress-response concept valid? [DOI]
  16. 16 Overexpression of monodehydroascorbate reductase in transgenic tobacco confers enhanced tolerance to ozone, salt and polyethylene glycol stresses [DOI]
  17. 17 The Maize Phytoene Synthase Gene Family: Overlapping Roles for Carotenogenesis in Endosperm, Photomorphogenesis, and Thermal Stress Tolerance [DOI]
  18. 18 Differential Effect of Saturated and Unsaturated Free Fatty Acids on the Generation of Monocyte Adhesion and Chemotactic Factors by Adipocytes [DOI]
  19. 19 Aluminium-induced production of oxygen radicals, lipid peroxidation and DNA damage in seedlings of rice (Oryza sativa) [DOI]
  20. 20 The nature and mechanism of superoxide production by the electron transport chain: Its relevance to aging [DOI]
  21. 21 Two-billion-year-old evaporites capture Earth’s great oxidation [DOI]
  22. 22 Ascorbate peroxidase from rice seedlings: properties of enzyme isoforms, effects of stresses and protective roles of osmolytes [DOI]
  23. 23 Key players of singlet oxygen-induced cell death in plants [DOI]
  24. 24 Oxidative Stress and Antioxidative Defense System in Plants Growing under Abiotic Stresses [DOI]
  25. 25 Purification and Characterization of Pea Cytosolic Ascorbate Peroxidase [DOI]
  26. 26 Analysis and Distribution of Vitamin E in Vegetable Oils and Foods [DOI]
  27. 27 Mitochondrial DNA and inflammatory diseases [DOI]
  28. 28 Flavonoids in Cancer Prevention [DOI]
  29. 29 Differential activity of catalase and superoxide dismutase in seedlings and in vitro micropropagated oak ( Quercus robur L.) [DOI]
  30. 30 Cadmium-induced oxidative stress in Saccharomyces cerevisiae.
  31. 31 Critical role of the NADPH oxidase subunit p47phox on vascular TLR expression and neointimal lesion formation in high-fat diet-induced obesity [DOI]
  32. 32 Some biochemical properties of guaiacol peroxidases as modified by salt stress in leaves of salt-tolerant and salt-sensitive safflower ( Carthamus tinctorius L.cv. ) cultivars [DOI]
  33. 33 Engineering tocopherol biosynthetic pathway in Arabidopsis leaves and its effect on antioxidant metabolism [DOI]

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