Investigation of the Interaction of Drug Tetradecyltrimethylammonium Bromide with Cetyltrimethylammonium Bromide at Different Temperature

Abstract

Antibiotic interaction between tetradecyltrimethylammonium bromide (TTAB) with cetyltrimethylammonium bromide (CTAB) has been studied in solution and within the attendance of salts at several temperatures (298.15, 303.15, 308.15, 313.15 and 318.15 K). One critical micelle concentration (CMC) was noted for pure CTAB and their mixture with the drug tetradecyltrimethylammonium bromide (TTAB). The CMC values for mixed systems (TTAB + CTAB) within the presence of salt exhibited lower in magnitude as compared to their absence. This acknowledged the first micellization of the mixture of TTAB and CTAB. All the G0m values were found to be negative for all systems. The H0m and S0m values disclosed that hydrophobic and electrostatic interactions were increased within the presence of salts compared to their absence at lower and better temperatures respectively. The opposite thermodynamics parameters like transfer energy (G0m.tr.), transfer enthalpy (H0m.tr.) also as transfer entropy (S0m.tr.) were also determined and discussed intimately. The inherent enthalpy gain (H0m) and therefore the compensation temperature (Tc) were also estimated and deliberated. Molecular dynamics simulation exposes that aqueous also as salt environment have an impact on the hydrophobic interaction between tetradecyltrimethylammonium bromide (TTAB) with cetyltrimethylammonium bromide (CTAB).