A Review of Anti-inflammatory Approaches in Atherosclerosis: Focus on CRP and Il-1 Pathway Inhibitors

Abstract

Atherosclerosis remains a leading cause of cardiovascular diseases, with chronic inflammation playing a critical role in its pathogenesis. This review evaluates various anti-inflammatory strategies targeting the C-reactive protein (CRP) and interleukin-1 (IL-1) pathways. Through a comprehensive analysis of recent clinical trials and preclinical studies, we highlight the potential of CRP and IL-1 inhibitors in mitigating inflammatory responses associated with atherosclerotic development. Our findings indicate that these therapeutic interventions may effectively reduce arterial plaque formation and improve cardiovascular outcomes. Furthermore, we discuss the challenges and limitations faced in translating these therapies into clinical practice. This review underscores the importance of continued research into anti-inflammatory modalities as viable options in the management of atherosclerosis, with particular emphasis on tailored approaches that target specific inflammatory pathways.