Tadalafil-Inducedhis to Morphological and Biochemical Alterations in the Prostate and Heart of Male Wistar Rats

Abstract

This study aims After a period of 14 days of acclimatization, twenty (20) healthy male albino rats were randomly allocated to four groups, control group(takes water only), low dose group (2.5mg/kg bw of tadalafil), medium dose group (5 mg/kg. b.w of tadalafil) and high dose group which takes (10 mg/kg b.w of tadalafil) The rats were subjected to tadalafil oral administration for twenty-eight consecutive days. The impact of the tadalafil on antioxidant enzymes activities of the prostate and heart homogenized tissue. All data in the table were expressed as mean ± standard deviation(SD), p-values for antioxidative stress markers analysis(SOD 0.25 ± 0.04, CAT1.22 ± 0.25, and MDA0.33 ± 0.07) were statistically significant at p<0.05), while the impact on the hormonal activities shows statistically significant dose-dependent effects of the substance on (PSA0.19 ± 0.02, testosterone7.46 ± 0.11, and tyrosinase-related protein 1 4.01 ± 0.15 (TRP1) level were all statistically significant at p<0.05 cut off mark to measure the level of significance. The histology shows that they were no significant changes in the histological structure of the prostate and heart tissues when given high dose with no indication of degeneration in the tissues. In summary, the study posits that owing to the regular and controlled use of tadalfil, it was efficacious in the treatment of erectile dysfunction while irregular and over use can results in some biochemical and hormonal changes in the prostate and heart of the rats.