Case Report: Hepatitis-associated Severe Aplastic Anemia of Unknown Etiology
Muditha Jayaweera, Wasantha Kodikaraarachchi, Himal Kalambarachchi
Asian Journal of Case Reports in Medicine and Health · pp. 110–116 · Published 30 Jul 2022
Abstract
Aplastic anemia (AA) is a life-threatening, autoimmune-mediated condition that targets bone marrow precursors leading to pancytopenia. Hepatitis-associated aplastic anemia (HAAA) is one of the rarest entities where the recovery of acute hepatitis is complicated by aplastic anemia. Hepatitis viruses (A-E, G), non-hepatitis viruses (cytomegalovirus, Epstein-Barr virus, HIV, Parvovirus B19, and echoviruses,) and drugs/toxins have been recognized as etiological agents. We present a case of a 29-year-old Asian male presenting with progressive jaundice, diagnosed to have acute cholestatic hepatitis, subsequently leading to severe aplastic anemia without an identified inciting agent.
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