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Research Article Open access CC BY 4.0

Vitamins C and E as Effective Protectors against Potassium Bromate-induced Cardiac Injury in Rats

Heba Barakat, Mai El-Sayed

Journal of Applied Life Sciences International · pp. 1–8 · Published 26 Aug 2016

10.9734/JALSI/2016/28697

Abstract

Potassium bromate (KBrO3) is widely used in foods and water, in spite of its well-known oxidative cell and tissue damage. Therefore, vitamins C and E are examined to alleviate its cardiac injury. For this purpose 72 adult male albino rats were categorized into 6 groups. Group1 served as control; group 2 served 30 mg/Kg/ day vitamin C; group 3 served 300 mg/kg/day vitamin E; group 4 was injected intraperitoneally with KBrO3 20 mg/Kg/ dose twice weekly; and groups 5 and 6 received either vitamins C or E with KBrO3 in the same scheme. After 4 weeks, heart and serum were collected for analysis. KBrO3-induced cardiac injury was evidenced by a significant increase in serum asparate transaminase (AST), creatine phosphokinase isoenzyme (CK-MB) and lactate dehydrogenase (LDH) activities and cardiac troponin I (cTnI) level. Significant reduction in cardiac collagen synthesis and elevation in matrix metalloproteinase-1 (MMP-1) and tumor necrosis factor-α (TNF-α) were noticed in KBrO3-intoxicated rats. These changes were ameliorated in the vitamins C and E-treated groups through their antioxidant and anti-inflammatory properties.

Vitamin C vitamin E potassium bromate cardiac troponin I collagen tumor necrosis factor

References (30)

  1. 1 A Colorimetric Method for the Determination of Serum Glutamic Oxalacetic and Glutamic Pyruvic Transaminases [DOI]
  2. 2 THE DETERMINATION OF COLLAGEN AND ELASTIN IN TISSUES [DOI]
  3. 3 Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts [DOI]
  4. 4 Chemistry and biology of vitamin E [DOI]
  5. 5 Interleukin-1β and Tumor Necrosis Factor-α Decrease Collagen Synthesis and Increase Matrix Metalloproteinase Activity in Cardiac Fibroblasts In Vitro [DOI]
  6. 6 Cadmium-induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and β-carotene [DOI]
  7. 7 Methods for monitoring oxidative stress, lipid peroxidation and oxidation resistance of lipoproteins [DOI]
  8. 8 Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats [DOI]
  9. 9 Cardiac troponin I is a sensitive, specific biomarker of cardiac injury in laboratory animals [DOI]
  10. 10 Effect of vitamin E on monosodium glutamate induced hepatotoxicity and oxidative stress in rats.
  11. 11 Cardioprotective effect of fluvastatin on isoproterenol-induced myocardial infarction in rat [DOI]
  12. 12 Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors. [DOI]
  13. 13 VITAMIN E AND NEUROLOGICAL FUNCTION [DOI]
  14. 14 α-Tocopherol decreases CD36 expression in human monocyte-derived macrophages [DOI]
  15. 15 Intracellular compartmentation of troponin T: Release kinetics after global ischemia and calcium paradox in the isolated perfused rat heart [DOI]
  16. 16 Comparison of the diagnostic value of cardiac troponin I and T determinations for detecting early myocardial damage and the relationship with histological findings after isoprenaline-induced cardiac injury in rats [DOI]
  17. 17 Vitamin C and Vitamin E in Prevention of Nonalcoholic Fatty Liver Disease (NAFLD) in Choline Deficient Diet Fed Rats [DOI]
  18. 18 Nigella sativa (black cumin) ameliorates potassium bromate-induced early events of carcinogenesis: diminution of oxidative stress [DOI]
  19. 19 Kolaviron Modulates cellular redox status and impairment of membrane protein activities induced by potassium bromate (KBrO3) in rats [DOI]
  20. 20 Prevention of KBrO 3 -induced cardiotoxicity by Sonchus asper in rat [DOI]
  21. 21 Creatine kinase: Evidence for a dimeric structure [DOI]
  22. 22 A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 1 (interstitial collagenase) using monoclonal antibodies [DOI]
  23. 23 Is there a role for antioxidant vitamins in the prevention of cardiovascular diseases? An update on epidemiological and clinical trials data.
  24. 24 Potassium Bromate-Induced Hyperuricemia Stimulates Acute Kidney Damage and Oxidative Stress [DOI]
  25. 25 Can vitamin C affect the KBrO3 induced oxidative stress on left ventricular myocardium of adult male albino rats? A histological and immunohistochemical study [DOI]
  26. 26 Controlling Myocardial Matrix Remodeling [DOI]
  27. 27 Vitamin C Intake and Apolipoproteins in a Healthy Elderly Japanese Population [DOI]
  28. 28 Contribution of Glutathione Peroxidase and Nitric Oxide to Potassium Bromate-Induced Oxidative Stress and Kidney Damage in Mice. [DOI]
  29. 29 Decision Making with Cardiac Troponin Tests [DOI]
  30. 30 Handbook of vitamin C research: daily requirements, dietary sources and adverse effects.

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