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Research Article Open access CC BY 4.0

Vitamin D, Calcium and Phosphorus Status Involvement during COVID-19 Infection

Abdalla Eltoum Ali, Mohamed Fathy Seyyed Ahmed, Somia Mohammed Suliman, Ibrahim Ahamed Ali Karti, Haidar Eltayeb Saleh

Asian Journal of Research in Biochemistry · pp. 29–38 · Published 8 Dec 2022

10.9734/ajrb/2022/v11i2214

Abstract

Background: COVID-19 is associated with a weak immune system in the human body. Vitamin D plays a role in the body’s immune system and is known to enhance the function of immune cells. In this case, vitamin D inhibits some of the inflammation that can make COVID-19 more severe. The is study aims to determine the serum levels of vitamin D, calcium, and phosphorus in COVID-19 patients. Methods: This was a cross sectional study conducted during the period from January 2021 to July 2021. 50 COVID-19 patients as a case study and 50 healthy individuals as a control group were included in this study. Blood samples were collected from the study group and measured for vitamin D using Enzyme-linked immunosorbent assay (ELISA) technique. Calcium and phosphate were measured by the Cobas 6000 fully automated analyzer (Roche, Germany). Results:  The study result showed that in COVID-19 patients, vitamin D (27 ± 5 ng/mL), p-value = 0.000, and calcium (10.2 ± 4 mg/dL), p-value = 0.000, in comparison with control. There was a correlation between vitamin D (r = -.771; p =.000) and calcium (r = -.752; p =.000) and the severity of disease. Conclusions: According to our research, vitamin D deficiency may increase the risk of developing COVID-19 and the risk of developing severe illnesses.

COVID -19 vitamin D calcium phosphate

References (39)

  1. 1 A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster [DOI]
  2. 2 Clinical and immunological features of severe and moderate coronavirus disease 2019 [DOI]
  3. 3 Features, Evaluation and Treatment Coronavirus (COVID-19)
  4. 4 The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) — China, 2020 [DOI]
  5. 5 Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths [DOI]
  6. 6 Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data [DOI]
  7. 7 Vitamin D Metabolism, Mechanism of Action, and Clinical Applications [DOI]
  8. 8 The cytokine storm and COVID‐19 [DOI]
  9. 9 Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam [DOI]
  10. 10 From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health [DOI]
  11. 11 Prevalence and correlates of vitamin D deficiency in US adults [DOI]
  12. 12 The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality [DOI]
  13. 13 Vitamin D and 1,25(OH)2D Regulation of T cells [DOI]
  14. 14 Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results [DOI]
  15. 15 Vitamin D-Directed Rheostatic Regulation of Monocyte Antibacterial Responses [DOI]
  16. 16 Electrolyte imbalances in patients with severe coronavirus disease 2019 (COVID-19) [DOI]
  17. 17 Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients [DOI]
  18. 18 Vitamin D, infections and immunity [DOI]
  19. 19 Prevalence of malnutrition and analysis of related factors in elderly patients with COVID-19 in Wuhan, China [DOI]
  20. 20 Vitamin D status has a linear association with seasonal infections and lung function in British adults [DOI]
  21. 21 Vitamin D metabolism and signaling in the immune system [DOI]
  22. 22 Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells [DOI]
  23. 23 Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes [DOI]
  24. 24 Emerging Role of Vitamin D and its Associated Molecules in Pathways Related to Pathogenesis of Thrombosis [DOI]
  25. 25 Serum vitamin D, calcium, and zinc levels in patients with COVID-19 [DOI]
  26. 26 COVID-19-associated coagulopathy [DOI]
  27. 27 Malnutrition Prolongs the Hospitalization of Patients with COVID-19 Infection: A Clinical Epidemiological Analysis [DOI]
  28. 28 Clinical Characteristics of Patients with Severe Pneumonia Caused by the SARS-CoV-2 in Wuhan, China [DOI]
  29. 29 High Prevalence of Hypocalcemia in Non-severe COVID-19 Patients: A Retrospective Case-Control Study [DOI]
  30. 30 Vitamin D attenuates rhinovirus-induced expression of intercellular adhesion molecule-1 (ICAM-1) and platelet-activating factor receptor (PAFR) in respiratory epithelial cells [DOI]
  31. 31 Immunoregulation of Inflammatory and Inhibitory Cytokines by Vitamin D 3 in Patients with Inflammatory Bowel Diseases [DOI]
  32. 32 Evaluation of the nutritional status in patients with COVID-19 [DOI]
  33. 33 A Correlation Analysis Between the Nutritional Status and Prognosis of COVID-19 Patients [DOI]
  34. 34 Vitamin D and COVID‐19—Revisited [DOI]
  35. 35 Risk of Malnutrition Is Common in Patients with Coronavirus Disease 2019 (COVID-19) in Wuhan, China: A Cross-sectional Study [DOI]
  36. 36 Analysis of influenza virus-induced perturbation in autophagic flux and its modulation during Vitamin D3 mediated anti-apoptotic signaling [DOI]
  37. 37 VITAMIN D AND CHILDHOOD PNEUMONIA
  38. 38 The link between vitamin D and COVID‐19: distinguishing facts from fiction [DOI]
  39. 39 Letter: Covid‐19, and vitamin D. Authors' reply [DOI]

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