Use of Gabapentin as an Adjunct Agent in the Treatment of Neonatal Abstinence Syndrome: A Case Report
Alyssa Brzenski, Mark Greenberg
International Journal of Medical and Pharmaceutical Case Reports · pp. 84–88 · Published 13 Mar 2015
10.9734/IJMPCR/2015/16142Abstract
We report the use of Gabapentin (Neurontin), an anticonvulsant and analgesic, as a non-opioid adjunct agent in the treatment of a term newborn infant with neonatal abstinence syndrome (NAS). Initial treatment with methadone to prevent withdrawal symptoms was not fully effective. Despite the addition of clonidine, an alpha-2 agonist, he was still unable to be weaned off opioids. The addition of gabapentin reduced symptoms, allowing for successful taper off methadone, and discharge from the hospital. As a non-opioid agent, gabapentin is a drug with potential for assisting with the difficult task of treating NAS refractory to standard opioid therapy due to its sedative and analgesic properties without any respiratory depression.
References (19)
- 1 Gabapentin for the Symptomatic Treatment of Painful Neuropathy in Patients With Diabetes Mellitus A Randomized Controlled Trial [DOI]
- 2 The Analgesic Effects of Gabapentin After Total Abdominal Hysterectomy [DOI]
- 3 Gabapentin in the treatment of neuropathic pain [DOI]
- 4 Analgesic Effects of Gabapentin after Spinal Surgery [DOI]
- 5 Management of neonatal abstinence syndrome in neonates born to opioid maintained women [DOI]
- 6 The Analgesic Effects of Gabapentin in Monitored Anesthesia Care for Ear-Nose-Throat Surgery [DOI]
- 7 Single‐Dose Gabapentin Pharmacokinetics and Safety in Healthy Infants and Children [DOI]
- 8 Management of the newborn infant affected by maternal opiates and other drugs of dependency [DOI]
- 9 Importance of Gabapentin Dose in Treatment of Opioid Withdrawal [DOI]
- 10 Use of gabapentin in the treatment of childhood reflex sympathetic dystrophy [DOI]
- 11 Use of clonidine in the prevention and management of neonatal abstinence syndrome [DOI]
- 12 Treatment of Pain With Gabapentin in a Neonate [DOI]
- 13 Management of Neonatal Abstinence Syndrome from Opioids [DOI]
- 14 Gabapentin in the management of reflex sympathetic dystrophy [DOI]
- 15 Gabapentin Blocks and Reverses Antinociceptive Morphine Tolerance in the Rat Paw-pressure and Tail-flick Tests [DOI]
- 16 Population pharmacokinetics of gabapentin in infants and children [DOI]
- 17 Effect of add‐on gabapentin on opioid withdrawal symptoms in opium‐dependent patients [DOI]
- 18 Gabapentin Therapy for Pain and Irritability in a Neurologically Impaired Infant [DOI]
- 19 Gabapentin as part of multimodal analgesia in a newborn with epidermolysis bullosa [DOI]
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Christopher McPherson · Neonatal Network · 2021
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