Synthesis, Spectroscopic and Docking Studies of Napthyl Substituted Di-Spiro Octahydroindolizine
R. Vishnu Priya, J. Suresh, S. Sivakumar, R. Ranjith Kumar, R. Sankaranarayanan
Physical Science International Journal · pp. 479–489 · Published 18 Jul 2013
Abstract
The crystal structure of spiro[2.2"]acenaphthene-1"-onespiro[3.3']-5'-(naphthylmethylidine)-1'-methylpiperidin-4'-one-4-(naphthyl)octahydroindolizine has been elucidated by modern spectroscopic technique including, 1H and 13C NMR spectroscopy and unequivocally confirmed by single crystal X-ray diffraction. The title compound C45H38N2O2, crystallizes in the tetragonal system, space group I41/a with a=39.692(5) Å, b= 39.692(5) Å, c= 8.793(5) Å, α = β = γ = 90°, V = 13852.98(83) A3. The central piperidine ring adopts twisted conformation, the piperidine of octahydroindolizine ring is in chair conformation and the pyrrole ring is in slightly twisted envelope conformation. Details of the synthesis, NMR, crystal structure determination and intra-molecular interaction of the compound are given. The molecular docking study of synthesized compound with an enzyme, namely, N-acetyl-gamma-glutamyl-phosphate reductase that is involved in arginine biosynthesis in M. tuberculosis (MtbAGPR) has also been carried out.
Cited by 0
No indexed citations yet.
Related research
- 13C NMR Spectroscopic Studies of Intra- and Intermolecular Interactions of Amino Acid Derivatives and Peptide Derivatives in Solutions — shares topic coverage
- Neighboring Nitrogen Atom-Induced Reactions of Azidoacetyl Hydrazides, including Unexpected Nitrogen-Nitrogen Bond Cleavage of the Hydrazide — shares topic coverage
- Harnessing Weak and Hydrogen Bonding Interactions for Tailored Crystal Formation: A Case Study of Diisopropylammonium Phenylsulfonate — shares topic coverage
- Crystallographic and Computational Insights into Hydrogen Bonding in Diisopropylammonium Hydrogenophthalate — shares topic coverage
- In vivo and In silico Anti Inflammatory Studies of Alstonia scholaris Bark Extract — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.