Traditional Uses and Anticancer Potential of the Combretum Genus: A Literature Review
European Journal of Medicinal Plants · pp. 22–39 · Published 31 Mar 2023
10.9734/ejmp/2023/v34i31127Abstract
Background: Cancer incidence is increasing annually in all countries. So, it is nowadays a great burden for the different nations of the world. Research for new therapeutics is becoming an urgent need, particularly for intractable and chemoresistant cancer cases. The solutions can still be found by investigating natural products which are recognized as promising sources of bioactive compounds with a potential for the discovery of new preventive and therapeutic anticancer agents. Methodology: The present work used databases such as Pubmed, Science Direct and Google scholar to investigate the ethnobotanical uses of some Combretum species in the literature. It also allowed us to summarize some pharmacological studies on Combretum species. Results: This review gathers all available traditional uses and cytotoxicity studies of Combretum species in the literature. Special focus is given to pharmacological studies highlighting isolated potential anticancer molecules. These molecules present potent cytotoxic effect on various cancer cell lines and may contribute to improving the health of people suffering from various cancer diseases. Conclusion: The Combretum species are widely used in folk medicine for the treatment of several pathologies including cancers. This study is of fundamental importance in highlighting Combretum species as a potential source for research of new anticancer compounds.
References (46)
- 1 Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries [DOI]
- 2 Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [DOI]
- 3 Global cancer statistics [DOI]
- 4 Global cancer statistics, 2012 [DOI]
- 5 Ethanolic Extract of Propolis (EEP) Enhances the Apoptosis- Inducing Potential of TRAIL in Cancer Cells [DOI]
- 6 The role and place of medicinal plants in the strategies for disease prevention [DOI]
- 7 Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4 [DOI]
- 8 Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy [DOI]
- 9 Anticancer Activity of Natural Compounds from Plant and Marine Environment [DOI]
- 10 Medicinal plants in Baskoure, Kourittenga Province, Burkina Faso: An ethnobotanical study [DOI]
- 11 Combretastatins: An Overview of Structure, Probable Mechanisms of Action and Potential Applications [DOI]
- 12 Clinical trial experience with CA4P anticancer therapy: focus on efficacy, cardiovascular adverse events, and hypertension management [DOI]
- 13 Methyl Quadrangularates A-D and Related Triterpenes from Combretum quadrangulare. [DOI]
- 14 Malaria in rural Burkina Faso: local illness concepts, patterns of traditional treatment and influence on health-seeking behaviour [DOI]
- 15 Differential cytotoxicity of Combretastatins A1 and A4 in two daunorubicin-resistant P388 cell lines [DOI]
- 16 Combretastatin A4 phosphate [DOI]
- 17 Antineoplastic Agents, 122. Constituents of Combretum caffrum [DOI]
- 18 Evaluation of 13 selected medicinal plants from Burkina Faso for their antiplasmodial properties [DOI]
- 19 The Synthesis of (E) and (Z)-Combretastatins A-4 and a Phenanthrene from Combretum caffrum [DOI]
- 20 Cytotoxic activity of selected Nigerian plants [DOI]
- 21 Antibacterial and cytotoxic triterpenoids from the roots of Combretum racemosum [DOI]
- 22 A phase I clinical trial assessing the safety and tolerability of combretastatin A4 phosphate injections [DOI]
- 23 Isolation and characterization of the compounds responsible for the antimutagenic activity of Combretum microphyllum (Combretaceae) leaf extracts [DOI]
- 24 Cytotoxic Phenanthrene, Dihydrophenanthrene, and Dihydrostilbene Derivatives and Other Aromatic Compounds from Combretum laxum [DOI]
- 25 HPLC-DAD and UHPLC/QTOF-MS Analysis of Polyphenols in Extracts of the African Species Combretum padoides, C. zeyheri and C. psidioides Related to Their Antimycobacterial Activity [DOI]
- 26 Myricitrin from Combretum lanceolatum Exhibits Inhibitory Effect on DNA-Topoisomerase Type II α and Protective Effect Against In Vivo Doxorubicin-Induced Mutagenicity [DOI]
- 27 The Effects of Combining Cancer Drugs with Compounds Isolated from Combretum zeyheri Sond. and Combretum platypetalum Welw. ex M.A. Lawson (Combretaceae) on the Viability of Jurkat T Cells and HL‐60 Cells [DOI]
- 28 Selective tumor cell growth inhibition by lignans and a seco-triterpenoid from Combretum mellifluum [DOI]
- 29 Combretastatin CA-4 and combretastatin derivative induce mitotic catastrophe dependent on spindle checkpoint and caspase-3 activation in non-small cell lung cancer cells [DOI]
- 30 Cytotoxic cycloartane-type triterpenes from Combretum quadrangulare [DOI]
- 31 Cytotoxic Pentacyclic Triterpenoids from Combretum sundaicum and Lantana camara as Inhibitors of Bcl-xL/BakBH3 Domain Peptide Interaction [DOI]
- 32 In vitro antitumor effect of a lignan isolated from Combretum fruticosum, trachelogenin, in HCT-116 human colon cancer cells [DOI]
- 33 The natural triterpene 3β,6β,16β-trihydroxy-lup-20(29)-ene obtained from the flowers of Combretum leprosum induces apoptosis in MCF-7 breast cancer cells [DOI]
- 34 Nanoparticles of Combretum quadrangulare leaf extract induce cytotoxicity, apoptosis, cell cycle arrest and anti-migration in lung cancer cells [DOI]
- 35 Vascular effects and antioxidant activity of two Combretum species from Democratic Republic of Congo [DOI]
- 36 Bioautography‐guided HPTLC–MS as a rapid hyphenated technique for the identification of antimicrobial compounds from selected South African Combretaceae species [DOI]
- 37 Cytotoxic pentacyclic triterpenes from Combretum nigricans [DOI]
- 38 A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors [DOI]
- 39 Acetylated Dammarane-Type Bisdesmosides from Combretum inflatum [DOI]
- 40 Cytotoxic Effects ofCombretum platypetalumWelw. ex M.A. Lawson subsp. oatesii (Rolfe) Exell (Combretaceae) Leaf Extracts on Jurkat T-cells and Reversal of Effects by Reduced Glutathione [DOI]
- 41 The hypoglycemic and cytotoxic activity of the leave extract of Combretum glutinosum Perr ex DC [DOI]
- 42 Cycloartanes from leaves of Combretum quadrangulare growing in Vietnam [DOI]
- 43 Antiplasmodial and Cytotoxic Flavans and Diarylpropanes from the Stems of Combretum griffithii [DOI]
- 44 Antidiarrhoeal activity of aqueous extract of Combretum sericeum roots in rats [DOI]
- 45 ANTITUMORAL, ANTIOXIDANT AND ANTIMICROBIAL MOLECULES FROM COMBRETUM RUPICOLA
- 46 Combretum Adenogonium Induce Anticancer and Antioxidant Effects in Prostate Cancer Cell Line [DOI]
Cited by 4
Adfar Reyaz, Syed Sanober Qadri, Darakhshan Javaid · Phytomedicine Plus · 2025
Showing 1 of 4 known citations — external sources report more than can currently be individually listed.
Related research
- A Novel Catalytic Synthesis of Flavones under Autoclave Conditions and Comparative Study of Anti-cancer Activity — shares topic coverage
- HPTLC Densitogram Profile of Aqueous Distillate (Arka) from Roots of Boerhaavia diffusa — shares topic coverage
- Effects of Ethanol Extract of Unripe Annona muricata (l.) Fruits on the Haematological and Histopathological Parameters in Swiss Albino Rats Infected with Salmonella typhi — shares topic coverage
- In vitro Efficacies of Some Nigerian Medicinal Plant Extracts against Toxigenic Aspergillus flavus, A. parasiticus and A. ochraceus — shares topic coverage
- Antimalarial Efficacy of Bergenia ciliata (Saxifragaceae) Leaf Extract In vitro against Plasmodium falciparum and In vivo against Plasmodium berghei — shares topic coverage
Article metrics
Real usage data collected on this platform.
45
Page views
0
PDF downloads
19
Outbound clicks
4
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.