Therapeutic Insights into Mangifera indica: Managing Diabetes and Hyperlipidemia in Alloxan-treated Rats

Abstract

People have used herbal medicine for healing since the dawn of human civilization. This study investigated the antidiabetic efficacy and lipid profile of Mangifera indica. We evaluated the antidiabetic activity through the alloxan-induced diabetic model. The 750 mg/kg dosage in group 6 yielded statistically significant findings (p < 0.05) regarding antidiabetic efficacy.The group receiving a 750 mg/kg dose exhibited statistically significant outcomes for total cholesterol, HDL, and triglycerides, with results of 197.40±6.28*, 52.21±4.47*, and 101.75±3.29*, respectively (p<0.05). However, no groups demonstrated statistically significant outcomes regarding LDL and triglyceride levels, despite a decrease in these parameters in the blood following the administration of the extract. No groups exhibited statistically significant outcomes regarding SGPT and SGOT; however, the levels of these two parameters decreased in the blood following the administration of the extract. In the kidney function test, urea and creatinine levels in group 6 demonstrated statistical significance (pp < 0.05 at a dosage of 750 mg/kg, with values of 990.42 ± 4.82 and 11.70 ± 0.82, respectively.