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Research Article Open access CC BY 4.0

Therapeutic Effect of Ethanol Extract of Anthocleista vogelii Stem Bark in the Treatment of Jaundice on Paracetamol-induced Hepatotoxicity in Adult Wistar Rats

B. A. Olatunji, C. U. Ogunka-Nnoka

Journal of Advances in Medical and Pharmaceutical Sciences · pp. 1–11 · Published 15 Jan 2020

10.9734/jamps/2019/v21i430145

Abstract

This study investigated therapeutic effect of ethanol extract of Anthocleista vogelii stem bark (EEAV) in the treatment of jaundice on paracetamol-induced hepatotoxicity in adult wistar rats. A total of 30 wistar rats weighing between 160-200 g were distributed into 6 groups comprising group 1 (normal control), group 2 (paracetamol 2 g/Kg bw), group 3 (paracetamol 2 g/Kg bw + Silymarin 100mg/Kg bw) and groups 4-6 (paracetamol 2 g/Kg bw each + 250, 500, & 1000 mg/Kg bw of EEAV, respectively). Experiment lasted for a period of 16 days. Paracetamol induction elevated liver indices and enzyme activities. However, administration of EEAV significantly reduced (p≤0.05) these effects in groups 3-6 when compared to group 2. A significant elevation (p≤0.05) was reported in creatinine, urea, sodium (Na+) and chloride (Cl-) when group 2 was compared with group 1. Haematological study showed that packed cell volume (PCV), haemoglobin (Hb) and red blood cell (RBC) levels significantly increased (p≤0.05) in treatment groups 3-6 when compared to group 2. The catalase (CAT) activity increased significantly (p≤0.05) in groups 3, 4 and 6 when compared to group 2. Liver histology showed normal hepatocytes architecture with normal central vein in group 1. Group 2 revealed a histologically distorted liver tissue while there was regeneration of hepatic cells in groups 3-6. The study revealed that EEAV could serve as potent herbal therapeutic agent in the treatment of jaundice triggered by paracetamol induction in adult wistar rats.

Ethanol extract Anthocleista vogelii stem bark paracetamol hepatotoxicity jaundice wistar rats.

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