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Research Article Open access CC BY 4.0

Theophylline Derivatives' In-vivo Analgesic and Anti-Inflammatory Activities

Faruk Alam, Ruhul Amin, Biplab Kumar Dey, Josef Yakin, Smriti Rekha Chanda Das, Mohidul Islam, Himangshu Deka, Republica Borgohain, Durgaprasad Kemisetti

Journal of Pharmaceutical Research International · pp. 144–152 · Published 14 Dec 2021

10.9734/jpri/2021/v33i57A33978

Abstract

The reaction of theophylline and chloro-acetyl chloride produced an exceptional series of substituted theophylline derivatives (3A-3D), followed by ammonium thiocyanate and substituted aromatic aldehyde, and these synthesized derivatives were screened to study their analgesic and anti-inflammatory activities. UV, IR, H-1 NMR, mass spectral data, and CHN activities were used to describe the compounds, which were shown to be considerably efficacious at 100 mg/kg p.o., as well as experimental results that were statistically significant at the p <0.01 and p <0.05 levels.

Theophylline analgesic anti-inflammatory

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