The Significance of Nigella sativa on Histomorphological Variations of Seminiferous Tubules in Doxorubicin Treated Albino Rats
Ashok Kumar, Anjum Rehman, Sadia Sundus, Saher Fatima, Zeeshan Ahmed, Asma Aijaz
Journal of Pharmaceutical Research International · pp. 23–33 · Published 17 Feb 2022
10.9734/jpri/2022/v34i12A35548Abstract
Objective: To analyze the impact of nigella sativa on Histomorphological changes in doxorubicin treated albino rats. Research Design: Experimental research. Abode of Study: Anatomy Department, BMSI, Karachi, Pakistan. Materials and Methods: Piloted on 40 albino rats for 35 days in the Anatomy Department of BMSI. They were 3-4 months old and about 221 to 238 gm in weight. Rats were separated into 4 groups, Ao, Bo, Co & Do. Ao represented as control, Bo recieved Doxorubicin (DOX) 0.003g/1000g/ at 7TH day intraperitonealy, Co recieved Nigella sativa 1000mg/1000g everyday oral along with Doxorubicin 0.003g/1000g/ at 7TH day intraperitonealy and Do recieved Nigella sativa 1000mg/kg everyday oral. At the end of experiment, rats were dissected and conserved slides for staining. Results: Bo showed loss of normal architecture of seminiferous tubules and diverse level of atrophy while condition was improved in Co which were given Doxorubicin with extract of Nigella sativa. Conclusion: Our result tells us that Nigella sativa amended the histomorphological changes.
References (23)
- 1 Biochemical and Biophysical Research Communications [DOI]
- 2 Protective effects of zinc oxide nanoparticles against doxorubicin induced testicular toxicity and DNA damage in male rats [DOI]
- 3 Palliative effect of curcumin on doxorubicin‐induced testicular damage in male rats [DOI]
- 4 Antioxidant and cytoprotective effects of Nigella sativa L. seeds on the testis of monosodium glutamate challenged rats [DOI]
- 5 Black Seed (Nigella Sativa) and its Constituent Thymoquinone as an Antidote or a Protective Agent Against Natural or Chemical Toxicities.
- 6 The impact of mesenchymal stem cells on doxorubicin‐induced testicular toxicity and progeny outcome of male prepubertal rats [DOI]
- 7 Thymoquinone is a protective agent that reduces the negative effects of doxorubicin in rat testis [DOI]
- 8 Assessment of protective potential of Nigella sativa oil against carbendazim- and/or mancozeb-induced hematotoxicity, hepatotoxicity, and genotoxicity [DOI]
- 9 Effects of doxorubicin on sperm DNA methylation in mouse models of testicular toxicity [DOI]
- 10 Effect of short- and medium-term toxicity of doxorubicin on spermatogenesis in adult Wistar rats [DOI]
- 11 Antioxidant activity of Spirulina platensis alleviates doxorubicin-induced oxidative stress and reprotoxicity in male rats [DOI]
- 12 Protective role of chrysin on doxorubicin‐induced oxidative stress and DNA damage in rat testes [DOI]
- 13 Selenium and a newly synthesized Thiocyanoacetamide reduce Doxorubicin gonadotoxicity in male rat [DOI]
- 14 Pravastatin attenuates testicular damage induced by doxorubicin – a stereological and histopatological study [DOI]
- 15 Effects of oral administration of black seed (Nigella sativa) oil on histomorphometric dynamics of testes and testosterone profile in rabbits [DOI]
- 16 Histopathological and Hormonal Evaluation of Interaction effects of Ethidium Bromide, Nigella sativa, and Silver Nanoparticle on Male Rat Fertility [DOI]
- 17 Prophylactic effect of Nigella sativa against lead acetate induced changes in spermiogram, reproductive hormones and gonadal histology of rats [DOI]
- 18 Assessment of therapeutic effects of Nigella sativa against chronic lead acetate-induced reproductive dysfunction in male Sprague-Dawley rats [DOI]
- 19 The preventive and curative role of Nigella sativa in poisoning cases. [DOI]
- 20 Effects of quercetin, sitagliptin alone or in combination in testicular toxicity induced by doxorubicin in rats
- 21 Protective efficacy of Nigella sativa oil against the harmful effects of formaldehyde on rat testicular tissue [DOI]
- 22 Journal of Basic and Clinical Physiology and Pharmacology [DOI]
- 23 Journal of Biochemical and Molecular Toxicology [DOI]
Cited by 0
No indexed citations yet.
Related research
- Anti-oxidative and Hepato-protective Effects of Pseudocedrela kotschyi against Paracetamol Induced Liver Damage: A Biochemical and Histological Evaluation in Rats — shares topic coverage
- Evaluation of the Estrogenic Activity of Ficus umbellata Aqueous Extract Using a Rabbit Vaginal Cytological Model — shares topic coverage
- Studies on Mortality and Histopathological Alteration on the Gills of Oreochromis niloticus Juveniles Following Exposure to Ethanolic Extract of Phramenthera capitata under Laboratory Conditions — shares topic coverage
- Evaluation of Chronic Administration of Metronidazole on the Morphological and Biochemical Parameters on the Cerebral Cortex of Adult Wistar Rats — shares topic coverage
- Effect of Antioxidant Vitamins and Minerals Supplementation on SOD, GPX, and CAT Induced Acute Ischaemic Stroke Albino Rats — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.