The Role of Hyperhomocysteinemia in the Pathogenesis of Thromboocclusive Diseases
Ibragim Abdulganievich Yusupov, Mubarik Dziyaudinovna Akaeva, Natalia Yurievna Stepanova, Nikita Vladimirovich Slysarenko, Omar Ruslanovich Gaidarbekov, Eldar Abdurahmanovich Saidov, KhavraAdamovna Dudugova, Zaytun Said-Magomedovna Dikieva, Alina Yuryevna Maslova
Journal of Pharmaceutical Research International · pp. 130–136 · Published 6 Nov 2021
10.9734/jpri/2021/v33i48A33229Abstract
Homocysteine is a sulfur-containing non-proteinogenic amino acid that is an intermediate product of methionine metabolism. With excessive accumulation of homocysteine in the body, a state of hyperhomocysteinemia occurs, which has attracted the attention of doctors since the middle of the last century and received a serious impetus for research after the publication of data on the role of hyperhomocysteinemia in the pathogenesis of thromboocclusive diseases. To date, there are more than 7.5 thousand scientific papers devoted to the study of hyperhomocysteinemia, monothematic international conferences on clinical and therapeutic aspects of hypermonocysteinemia are held every year. In the Russian Federation, a detailed study of the role of homocysteine and its side effects in excess is of particular interest due to the prevalence of cardiovascular pathologies (according to statistics of the Ministry of Health of Russia-49.27% of deaths of Russians fall on this cohort of diseases). This is an important fact in Russian medicine, which deserves close attention from researchers and scientists.
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