Skip to content
Research Article Open access CC BY 4.0

The Potential Pharmacological and Medicinal Properties of Neem (Azadirachta indica A. Juss) in the Drug Development of Phytomedicine

E. A. Tembe-Fokunang, Fokunang Charles, Nubia Kaba, Gatsing Donatien, Agbor Michael, Ngadjui Bonaventure

Journal of Complementary and Alternative Medical Research · pp. 1–18 · Published 23 Mar 2019

10.9734/jocamr/2019/v7i130093

Abstract

An understanding of the chemistry of the secondary metabolites of neem plant (Azadirachta indica A. Juss) is essential and important due to its medicinal properties. Several studies have been done on the biological and pharmacological activities with a considerable progress made with respect to its biological activity and medicinal uses. The neem safety is known from its long communal ethno-pharmacological uses as a category one herbal product. It is readily available with great access to the local population at low cost and environmentally friendly. This paper attempts to give an insight into the biological activities of some of the compounds isolated, pharmacological actions of the extract, clinical studies and medicinal applications along with their safety evaluations. Issues on the active chemical constituents of various formulations, commercially available neem products, are also mentioned along with their respective application.

Neem Azadirachta indica pharmacological biological properties bio-pesticides agrochemicals drug development.

References (30)

  1. 1 Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment [DOI]
  2. 2 Medicinal Properties of Neem Leaves: A Review [DOI]
  3. 3 Azadirachta indica : A herbal panacea in dentistry - An update [DOI]
  4. 4 Neem (Azadirachta indica): An indian traditional panacea with modern molecular basis [DOI]
  5. 5 Neem ( Azadirachta indica ): towards the ideal insecticide? [DOI]
  6. 6 Endophytic Mycoflora and Their Bioactive Compounds from Azadirachta Indica: A Comprehensive Review [DOI]
  7. 7 Diabetes-related amputations create considerable public health burden in the UK [DOI]
  8. 8 Antiplasmodial Triterpenoids from the Fruits of Neem, Azadirachta indica [DOI]
  9. 9 Complementary and Alternative Medicine for Psoriasis: What the Dermatologist Needs to Know [DOI]
  10. 10 Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer [DOI]
  11. 11 Antibacterial efficacy of Azadirachta indica, Mimusops elengi and 2% CHX on multispecies dentinal biofilm [DOI]
  12. 12 Isolation and identification of the antibacterial active compound from petroleum ether extract of neem oil [DOI]
  13. 13 Control of biting lice, Mallophaga − a review [DOI]
  14. 14 Sublethal concentrations of azadirachtin affect food intake, conversion efficiency and feeding behaviour of Spodoptera littoralis (Lepidoptera: Noctuidae) [DOI]
  15. 15 Guaiane Sesquiterpene Lactones and Amino Acid-Sesquiterpene Lactone Conjugates from the Aerial Parts of Saussurea pulchella [DOI]
  16. 16 Cytotoxic Acylated Triterpene Saponins from the Husks of Xanthoceras sorbifolia [DOI]
  17. 17 Insights into bovine endometritis with special reference to phytotherapy [DOI]
  18. 18 Effects of azadirachtin on the regulation of midgut peristalsis by the stomatogastric nervous system inLocusta migratoria [DOI]
  19. 19 Efficacy of Specific Plant Products on Dental Caries Causing Microorganisms [DOI]
  20. 20 Toxicity of neem seed oil against the larvae ofBoophilus decoloratus, a one-host tick in cattle [DOI]
  21. 21 Biodiesel from plant seed oils as an alternate fuel for compression ignition enginesâa review
  22. 22 Bicyclic Polyketide Lactones from Chinese Medicinal Ants, Polyrhacis lamellidens [DOI]
  23. 23 Terpenoids from the Stems of Cipadessa baccifera [DOI]
  24. 24 Differential thresholds of azadirachtin for feeding deterrence and toxicity in locusts and an aphid [DOI]
  25. 25 Azadirachta indica A. Juss. (Neem Tree): In Vitro Culture, Micropropagation, and the Production of Azadirachtin and Other Secondary Metabolites [DOI]
  26. 26 Glycosides from the Bark of Adina polycephala [DOI]
  27. 27 Behavioural and neurophysiological responses of Spodoptera littoralis to azadirachtin and a range of synthetic analogues [DOI]
  28. 28 The effects of azadirachtin‐treated diets on the feeding behaviour and fecundity of the peach‐potato aphid, Myzus persicae [DOI]
  29. 29 Differential cytotoxic effects of azadirachtin on Spodoptera frugiperda and mouse cultured cells [DOI]
  30. 30 Ultra structural study of the rat cheek epithelium treated with Neem extract.

Cited by 50

Endophytic Bacillus aerophilus from the Leaves of Azadirachta indica as a Potential Biocontrol against Staphylococcus aureus

Peter Kasyula Mwendwa, Anncarol W. Karanja, John M. Maingi · Journal of Advances in Microbiology · 2023

A Mini-review on the Phytochemistry and Pharmacobiology of Azadirachta indica A. Juss. (Meliaceae): Towards future research directions

Blaise Mbembo Wa Mbembo, Colette Masengo Ashande, Lionel Asamboa Shotsha, Samy Ngunde Te Ngunde, Blanchard Mayele Masasi, Joseph Tshidibi Dipa, Sylvain Zogi Ngbo, Jean-Jacques Amogu Domondo, Dorothée D. Tshilanda, Damien S. T. Tshibangu, Pius T. Mpiana, Koto-Te-Nyiwa Ngbolua · Journal of Complementary and Alternative Medical Research · 2021

An Overview of Methods of Extraction, Isolation and Characterization of Natural Medicinal Plant Products in Improved Traditional Medicine Research

Dobgima John Fonmboh, Ejoh Richard Abah, Tembe Estella Fokunang, Bayaga Herve, Gerald Ngo Teke, Ngono Mballa Rose, Njinkio Nono Borgia, Lovet Benyella Fokunang, Banin Nyuyki Andrew, Nubia Kaba, Ngameni Bathelemy, Fokunang Charles Ntungwen · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2020

Physicochemical Characterization and Storage Stability of Neem-Cell Extract–Citronella Nanoemulsions Produced by Two-Step Homogenization

Duván Enrique Dueñas-López, Misael Cortés-Rodríguez, F. Orozco-Sánchez · BioNanoScience · 2026

Pharmacognostic And Pharmacological Evaluation of Azadirachta Indica Leaves for Anti-Diabetic Activity

B. Mishra, Swalin Parija, Debashisa Mishra · International Journal of Pharmacognosy and Herbal Drug Technology · 2025

Synergistic toxic and contraceptive potential of neem seed extract and andrographolide-based bait against black rat, Rattus rattus

Meenu Verma, Harjinder Kaur, B. K. Babbar · Zeitschrift f\ ur Jagdwissenschaft · 2024

Solid Lipid Nanoparticles for the Delivery of Plant-derived Bioactive Compounds in the Treatment of Cancer Disorders – A Review

K. S. Samanthula, Satya Obbalareddy, Ravi Chander Thatipelli · Journal of Natural Remedies · 2024

Showing 31 of 50 known citations — external sources report more than can currently be individually listed.

Article metrics

Real usage data collected on this platform.

289

Page views

0

PDF downloads

49

Outbound clicks

50

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.