The Possible Protective Effect of Metformin in COVID-19 Infection
Journal of Advances in Medical and Pharmaceutical Sciences · pp. 1–5 · Published 20 Oct 2020
10.9734/jamps/2020/v22i830185Abstract
Coronavirus 2019 (COVID-19) infections with more than 30 million confirmed cases are increasing rapidly, requiring urgent and safe treatment. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a virus responsible for the infection of COVID-19. Metformin (M) is a biguanide drug used as a first choice for the management of hyperglycemia in type 2 diabetes mellitus (T2DM). Furthermore, it is safe and currently available. It is speculated that metformin can be used for T2DM patients with COVID-19, because in addition to its hypoglycemic effect, this biguanide also shows many beneficial effects, including anti-inflammatory effects and cardiopulmonary protection especially by angiotensin converting enzyme 2 (ACE2) targeting. Therefore, the reasons for the use of metformin in COVID-19 patients were discussed in this study. Metformin has a promising role in treatment of COVID-19 in T2DM and obese women patients.
References (31)
- 1 COVID-19: consider cytokine storm syndromes and immunosuppression [DOI]
- 2 Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation [DOI]
- 3 Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor [DOI]
- 4 Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2 [DOI]
- 5 Tumor Necrosis Factor-α Signaling in Macrophages [DOI]
- 6 The ACE2/Angiotensin-(1–7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1–7) [DOI]
- 7 Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status [DOI]
- 8 Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence [DOI]
- 9 Update on Neutrophil Function in Severe Inflammation [DOI]
- 10 Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages [DOI]
- 11 Metformin and risk of mortality in patients hospitalised with COVID-19: a retrospective cohort analysis [DOI]
- 12 The microgenderome revealed: sex differences in bidirectional interactions between the microbiota, hormones, immunity and disease susceptibility [DOI]
- 13 AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension [DOI]
- 14 Metformin and COVID-19: From cellular mechanisms to reduced mortality [DOI]
- 15 Metformin inhibits HMGB1 release in LPS‐treated RAW 264.7 cells and increases survival rate of endotoxaemic mice [DOI]
- 16 Circulating angiotensin peptides levels in Acute Respiratory Distress Syndrome correlate with clinical outcomes: A pilot study [DOI]
- 17 Assessment of risk, severity, mortality, glycemic control and antidiabetic agents in patients with diabetes and COVID-19: A narrative review [DOI]
- 18 ACE2, Metformin, and COVID-19 [DOI]
- 19 Metformin and COVID‐19: A novel deal of an old drug [DOI]
- 20 Sexual dimorphism in the mast cell transcriptome and the pathophysiological responses to immunological and psychological stress [DOI]
- 21 Role of Diabetes in the Development of Acute Respiratory Distress Syndrome* [DOI]
- 22 Neutrophil gelatinase associated lipocalin (NGAL) is elevated in type 2 diabetics with carotid artery stenosis and reduced under metformin treatment [DOI]
- 23 Sex-dependent difference in the effect of metformin on colorectal cancer-specific mortality of diabetic colorectal cancer patients [DOI]
- 24 Metformin attenuates myocardial remodeling and neutrophil recruitment after myocardial infarction in rat [DOI]
- 25 Metformin ameliorates gender-and age-dependent hemodynamic instability and myocardial injury in murine hemorrhagic shock [DOI]
- 26 Metformin, neutrophils and COVID-19 infection [DOI]
- 27 Melatonin Potentiates the Therapeutic Effects of Metformin in Women with Metabolic Syndrome [DOI]
- 28 The effects of metformin on the fibrinolytic system in diabetic and non-diabetic subjects.
- 29 Capillary endothelia from two ADPKD patients are polyploidy.
- 30 Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by COVID-19: anti-inflammatory strategies. [DOI]
- 31 A proposed mechanism for the possible therapeutic potential of Metformin in COVID-19 [DOI]
Cited by 0
No indexed citations yet.
Related research
- Influence of Vitamin D Level on Diabetic Dyslipidemia — shares topic coverage
- Prevalence of Non-Communicable Diseases in Patients with Type 2 Diabetes Mellitus in Egypt; A Retrospective Survey — shares topic coverage
- No Association between Helicobacter Pylori Infection and Type 2 Diabetes Mellitus; A Case-control Study in the North-Western Part of Ghana — shares topic coverage
- Relationship between Body Mass Index and Low-Density Lipoprotein and Triglycerides in Type 2 Diabetes Mellitus Patients — shares topic coverage
- Clinical Case Series on Assessment of Therapeutic Efficacy of Saroglitazar in MASLD Patients — shares topic coverage
Article metrics
Real usage data collected on this platform.
75
Page views
0
PDF downloads
44
Outbound clicks
0
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.