The Locus of Fat Over-Accumulation as Predictor of Cardiometabolic Risks among Non Obese Normotensive Adults

Abstract

Studies on Metabolic Syndrome (MS) have recently been narrowed down to fat over-accumulation but there is no consistency in the obesity requirements for any of the health risk scores and definitions, thus, the utility of anthropometric measures in cardiometabolic risks prediction among non-obese requires additional research. This cross sectional study assessed the relationships and predictabilities of visceral adiposity index (VAI) and Lipid accumulation product (LAP) for cardiometabolic risks among 174 non obese adults (91 males and 83 females) 35 - 70 years of age that was randomly selected for this study after their consent. Anthropometric evaluation included weight, height, hip and waist circumferences. BMI, Waist-height ratio and waist-hip ratio were calculated. Serum Triglyceride and High Density Lipoprotein measured in a 12 hour fasting condition (mmol/L) using standard laboratory techniques were recorded. The VAI and LAP scores were calculated using the gender-specific equations. Systolic blood pressure and Diastolic blood pressure were measured and MABP was calculated as: DBP + 1/3 Pulse Pressure (mm/Hg). The results showed significant correlations among LAP, VAI, WHTR, WHPR and BMI (p≤0.01). Multivariate correlations and regression analysis of measures of adiposity and MS features also showed that LAP had a greater impact on features of MS and superior to other adiposity measures in male and female (R2: 0.956; p≤0.01). In conclusion, this study shows that LAP is superior in predicting risks of lipid and visceral adipose over-accumulations than other measures of adiposity among non-obese adults. The use of LAP as an assessment tool for Risks of fat over-accumulations and its intervention among non-obese adults was suggested.