The Importance of Targeted Drug Delivery Systems on Pancreatic Cancer
Current Journal of Applied Science and Technology · pp. 2400–2416 · Published 17 Apr 2014
10.9734/BJAST/2014/9671Abstract
Pancreatic cancer (PC) is the fourth type of cancer-related death in the world. There is estimated 45,220 new cases of PC will be diagnosed and 38,460 people will be passed away from the disease in the near future. The absence of diagnostic and prognostic markers and also unresponsiveness to current therapies including radiation and chemotherapies are major barriers against successful therapy even in the initial stage. The current therapies is not sufficient to provide effective treatment for PC patients due torapiddrug solubility and metabolism, insufficient drug concentration at the specific site and adverse side effects. To eliminate this disadvantages, nanoparticle based drug delivery systems have been investigated.In this review, we try to reveal the genetic and molecular mechanism which cause PC and emphasize the importance of targeted drug delivery systems for the disease.
References (121)
- 1 TOR, a Central Controller of Cell Growth [DOI]
- 2 Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer [DOI]
- 3 A transforming mutation in the pleckstrin homology domain of AKT1 in cancer [DOI]
- 4 Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma [DOI]
- 5 Solid lipid nanoparticles: A modern formulation approach in drug delivery system [DOI]
- 6 Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas.
- 7 Mutation of the PIK3CA oncogene in human cancers [DOI]
- 8 p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions.
- 9 Germline and Somatic Mutations of the STK11/LKB1 Peutz-Jeghers Gene in Pancreatic and Biliary Cancers [DOI]
- 10 High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma [DOI]
- 11 HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas [DOI]
- 12 Single Chain Epidermal Growth Factor Receptor Antibody Conjugated Nanoparticles for in vivo Tumor Targeting and Imaging [DOI]
- 13 Multi-functional polymeric nanoparticles for tumour-targeted drug delivery [DOI]
- 14 The Impact of Nanobiotechnology on the Development of New Drug Delivery Systems [DOI]
- 15 The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma.
- 16 Immunohistochemical Labeling for Dpc4 Mirrors Genetic Status in Pancreatic Adenocarcinomas [DOI]
- 17 The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-κB and c-Myc in pancreatic cancer cells [DOI]
- 18 Incidence, mechanism and prognostic value of activated AKT in pancreas cancer [DOI]
- 19 BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) Mutations in Distinct Subsets of Pancreatic Cancer [DOI]
- 20 Potential Tumor Suppressive Pathway Involving DUSP6/MKP-3 in Pancreatic Cancer [DOI]
- 21 3,3′-Diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5 [DOI]
- 22 Vascular endothelial growth factor receptor‐1 promotes migration and invasion in pancreatic carcinoma cell lines [DOI]
- 23 Cerium oxide nanoparticles: potential applications for cancer and other diseases.
- 24 Oncogene- and tumor suppressor gene-mediated suppression of cellular senescence [DOI]
- 25 Nanotechnology and Drug Delivery Part 2: Nanostructures for Drug Delivery [DOI]
- 26 O-Carboxymethyl chitosan nanoparticles for metformin delivery to pancreatic cancer cells [DOI]
- 27 Pancreatic Cancer [DOI]
- 28 Frequent c-Ki-ras oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation.
- 29 Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor.
- 30 ACVR1B ( ALK4 , activin receptor type 1B) gene mutations in pancreatic carcinoma [DOI]
- 31 Radiofrequency field‐induced thermal cytotoxicity in cancer cells treated with fluorescent nanoparticles [DOI]
- 32 Missense Mutations of MADH4 [DOI]
- 33 KLF4 is a Novel Candidate Tumor Suppressor Gene in Pancreatic Ductal Carcinoma [DOI]
- 34 Multifunctional Fe3O4 nanoparticles for targeted bi-modal imaging of pancreatic cancer [DOI]
- 35 SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt/β-catenin signaling [DOI]
- 36 Formulation, optimization and evaluation of spray-dried mucoadhesive microspheres as intranasal carriers for Valsartan [DOI]
- 37 Transcriptional Network Governing the Angiogenic Switch in Human Pancreatic Cancer [DOI]
- 38 Molecular targeting therapy for pancreatic cancer: current knowledge and perspectives from bench to bedside [DOI]
- 39 Inhibition of Amyloid Precursor Protein Processing Enhances Gemcitabine-mediated Cytotoxicity in Pancreatic Cancer Cells [DOI]
- 40 Kinase signaling pathways as targets for intervention in pancreatic cancer [DOI]
- 41 K- RAS Mutation in the Screening, Prognosis and Treatment of Cancer [DOI]
- 42 p53-independent expression of the cyclin-dependent kinase inhibitor p21 in pancreatic carcinoma.
- 43 K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.
- 44 siRNA targeting HIF-1alpha induces apoptosis of pancreatic cancer cells through NF-kappaB-independent and -dependent pathways under hypoxic conditions.
- 45 Apoptosis of pancreatic cancer BXPC-3 cells induced by indole-3-acetic acid in combination with horseradish peroxidase [DOI]
- 46 RETRACTED: Knockdown of Snail Sensitizes Pancreatic Cancer Cells to Chemotherapeutic Agents and Irradiation [DOI]
- 47 Pancreatic Cancer: Factors Regulating Tumor Development, Maintenance and Metastasis [DOI]
- 48 Development of gene therapy to target pancreatic cancer [DOI]
- 49 Chemotherapy in pancreatic cancer [DOI]
- 50 Pancreatic Cancer: Current Concepts in Invasion and Metastasis [DOI]
- 51 Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses [DOI]
- 52 Vascular endothelial growth factor (VEGF) and its receptors [DOI]
- 53 Solid lipid nanoparticles Production, characterization and applications [DOI]
- 54 Therapeutic Nanoparticles for Drug Delivery in Cancer [DOI]
- 55 DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1 [DOI]
- 56 Nanoparticle and targeted systems for cancer therapy [DOI]
- 57 DPC4 Gene Status of the Primary Carcinoma Correlates With Patterns of Failure in Patients With Pancreatic Cancer [DOI]
- 58 Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy [DOI]
- 59 The Regulation of INK4/ARF in Cancer and Aging [DOI]
- 60 The PTEN/PI3K/AKT Signalling Pathway in Cancer, Therapeutic Implications [DOI]
- 61 The Two TORCs and Akt [DOI]
- 62 The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells [DOI]
- 63 Fabrication of gold nanoparticles for targeted therapy in pancreatic cancer [DOI]
- 64 Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis [DOI]
- 65 Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma [DOI]
- 66 miR-146a Suppresses Invasion of Pancreatic Cancer Cells [DOI]
- 67 Hypermethylation of multiple genes in pancreatic adenocarcinoma.
- 68 SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells [DOI]
- 69 Sensitization of pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production [DOI]
- 70 The Pathology and Genetics of Metastatic Pancreatic Cancer [DOI]
- 71 Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas.
- 72 STK11/LKB1 Peutz-Jeghers Gene Inactivation in Intraductal Papillary-Mucinous Neoplasms of the Pancreas [DOI]
- 73 Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy [DOI]
- 74 Systemic Administration of Polymeric Nanoparticle-Encapsulated Curcumin (NanoCurc) Blocks Tumor Growth and Metastases in Preclinical Models of Pancreatic Cancer [DOI]
- 75 Transcriptional network governing the angiogenic switch in human pancreatic cancer [DOI]
- 76 Liposome based delivery systems in pancreatic cancer treatment: From bench to bedside [DOI]
- 77 Imaging Pancreatic Cancer with a Peptide−Nanoparticle Conjugate Targeted to Normal Pancreas [DOI]
- 78 miRNA-141, Downregulated in Pancreatic Cancer, Inhibits Cell Proliferation and Invasion by Directly Targeting MAP4K4 [DOI]
- 79 Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c [DOI]
- 80 Epidermal Growth Factor Receptor Expression in Pancreatic Carcinoma Using Tissue Microarray Technique [DOI]
- 81 Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and Caveolin-1 [DOI]
- 82 HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells [DOI]
- 83 Parthenolide induces proliferation inhibition and apoptosis of pancreatic cancer cells in vitro [DOI]
- 84 Mucin 16 is a functional selectin ligand on pancreatic cancer cells [DOI]
- 85 Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family [DOI]
- 86 Mechanistic studies of Gemcitabine-loaded nanoplatforms in resistant pancreatic cancer cells [DOI]
- 87 Antitumor Effects of Rapamycin in Pancreatic Cancer Cells by Inducing Apoptosis and Autophagy [DOI]
- 88 Knockdown of clusterin sensitizes pancreatic cancer cells to gemcitabine chemotherapy by ERK1/2 inactivation [DOI]
- 89 G 1 cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: Phenotypes reversed by a tumorigenic mutation [DOI]
- 90 Membrane proteomic analysis of pancreatic cancer cells [DOI]
- 91 Induction of Apoptosis in Tumor-Associated Endothelial Cells and Therapy of Orthotopic Human Pancreatic Carcinoma in Nude Mice [DOI]
- 92 Correlation between B7-H3 expression and matrix metalloproteinases 2 expression in pancreatic cancer [DOI]
- 93 Induction of Apoptosis and Autophagy in Human Pancreatic Cancer Cells by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin [DOI]
- 94 Early Effects of Lasonolide A on Pancreatic Cancer Cells [DOI]
- 95 αVintegrin: A new gastrin target in human pancreatic cancer cells [DOI]
- 96 Chemotherapy for pancreatic cancer [DOI]
- 97 Novel therapies for pancreatic adenocarcinoma [DOI]
- 98 RASSF2 Induces Activated Ras-Dependent Cell Growth Inhibition and Apoptosis in Human Pancreatic Cancer Cells
- 99 Induction of Apoptosis and Anoikis by Bit1 in Pancreatic Cancer Cells [DOI]
- 100 Genetics and biology of pancreatic ductal adenocarcinoma [DOI]
- 101 Mutations of the BRAF gene in human cancer [DOI]
- 102 EGFR Antagonists in Cancer Treatment [DOI]
- 103 Recent progress in pancreatic cancer [DOI]
- 104 The Prevalence of BRCA2 Mutations in Familial Pancreatic Cancer [DOI]
- 105 Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment [DOI]
- 106 Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors [DOI]
- 107 Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis [DOI]
- 108 RGD-conjugated albumin nanoparticles as a novel delivery vehicle in pancreatic cancer therapy [DOI]
- 109 Treatment of Pancreatic Cancer Cells with Dicumarol Induces Cytotoxicity and Oxidative Stress [DOI]
- 110 Design of Nanoparticles as Drug Carriers for Cancer Therapy.
- 111 EGFR Antagonists in Cancer Treatment [DOI]
- 112 Resveratrol induces apoptosis in pancreatic cancer cells.
- 113 Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma.
- 114 Cyclooxygenase-2-dependent and -independent effects of celecoxib in pancreatic cancer cell lines [DOI]
- 115 Enhanced Sensitivity of Pancreatic Cancer Cells to Concurrent Inhibition of Aberrant Signal Transducer and Activator of Transcription 3 and Epidermal Growth Factor Receptor or Src [DOI]
- 116 Expression of the tumor suppressor ARHI inhibits the growth of pancreatic cancer cells by inducing G1 cell cycle arrest [DOI]
- 117 Novel therapies for pancreatic adenocarcinoma [DOI]
- 118 Imprinted tumor suppressor gene ARHI induces apoptosis correlated with changes in DNA methylation in pancreatic cancer cells [DOI]
- 119 Suppression of human pancreatic cancer cell proliferation by AGN194204, an RXR-selective retinoid [DOI]
- 120 Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and Caveolin-1 [DOI]
- 121 Pancreatic Cancer: Factors Regulating Tumor Development, Maintenance and Metastasis [DOI]
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