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Research Article Open access CC BY 4.0

The Expression Patterns of APC2 and APC7 in Newly Diagnosed Acute Lymphoblastic Leukemia

Mohammad Reza Khosravi Farsani, ‏Vahid Amiri, Abbas Hajifathali, Mohamadhossein Mohammadi, Mohammad Jabari, Mehdi Allahbakhshian Farsani, Majid Asadi-Samani

Journal of Pharmaceutical Research International · pp. 1–8 · Published 28 Oct 2017

10.9734/JPRI/2017/36743

Abstract

Acute lymphoblastic leukemia (ALL) is a heterogeneous type of disease that is currently categorized based on cell morphology, immunophenotype, genetic abnormalities and gene expression pattern. Although these classifications are valuable in the determination of patient’s survival and treatment intensity, the response of patients to treatment and subsequently their survival are highly different, even in each subtype. So searching for new molecules involved in the leukemogenesis, disease progression, treatment resistance or candidate targets for therapy are critically sensed. APC/C is a multi-subunit E3 ligase that has essential role in metaphase progression and seems to be essentially involved in tumorgenesis and cancer progression. We analyzed the expression of APC2 and APC7 gene as two key subunits of this complex in 57 newly diagnosed ALL patients with quantitative RT-PCR. APC2 and APC7 were significantly over-expressed in 33 (57.9%) and 38 (66.7%) of patients respectively (P value of 0.014 and 0.009) using two-tailed Student’s t tests. This over expression was independent of cellular, immunological and molecular factors. APC/C promotes cell proliferation, a feature related to tumorgenesis and also poor prognosis in cancers such as ALL, so the determination of the pattern of APC/C subunits gene expression may help to better understand molecular basic underlying cancer and also new prognostic marker and new targets for therapy in ALL patients.

Cancer cell proliferation diagnosis leukemogenesis

References (23)

  1. 1 Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction [DOI]
  2. 2 Analyzing real-time PCR data by the comparative CT method [DOI]
  3. 3 World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects [DOI]
  4. 4 Proposals for the Classification of the Acute Leukaemias F rench ‐A merican ‐B ritish (FAB) C o‐operative G roup [DOI]
  5. 5 Acute Lymphoblastic Leukemia in Children [DOI]
  6. 6 Treatment of Acute Lymphoblastic Leukemia [DOI]
  7. 7 Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling [DOI]
  8. 8 Acute lymphoblastic leukaemia [DOI]
  9. 9 Modern Therapy of Acute Lymphoblastic Leukemia [DOI]
  10. 10 Mitotic Regulation of the APC Activator Proteins CDC20 and CDH1 [DOI]
  11. 11 Mitotic regulation of the human anaphase‐promoting complex by phosphorylation [DOI]
  12. 12 Pharmacologic Inhibition of the Anaphase-Promoting Complex Induces A Spindle Checkpoint-Dependent Mitotic Arrest in the Absence of Spindle Damage [DOI]
  13. 13 Atomic structure of the APC/C and its mechanism of protein ubiquitination [DOI]
  14. 14 APC/CCdc20 Controls the Ubiquitin-Mediated Degradation of p21 in Prometaphase [DOI]
  15. 15 Insights into APC/C: from cellular function to diseases and therapeutics [DOI]
  16. 16 A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-like Cells [DOI]
  17. 17 Alterations of anaphase-promoting complex genes in human colon cancer cells [DOI]
  18. 18 Oncogenic Regulators and Substrates of the Anaphase Promoting Complex/Cyclosome Are Frequently Overexpressed in Malignant Tumors [DOI]
  19. 19 Bub3–BubR1-dependent sequestration of Cdc20Fizzy at DNA breaks facilitates the correct segregation of broken chromosomes [DOI]
  20. 20 Proliferation of normal and malignant human immature lymphoid cells [DOI]
  21. 21 Cell cycle regulatory gene abnormalities are important determinants of leukemogenesis and disease biology in adult acute lymphoblastic leukemia. [DOI]
  22. 22 The growth of highly proliferative acute lymphoblastic leukemia may be independent of stroma and/or angiogenesis [DOI]
  23. 23 Prognostic value of the rapidity of bone marrow blast cell proliferation in adult acute lymphoblastic leukemia [DOI]

Cited by 2

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A. Ahmadzadeh, M. Mohammadi, F. Mezginezhad · 2018

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