The Effect of Retinoic Acid on the Development of Neural Tube at Early Stages of Chicken Embryo
Kawakeb A. Saad, Eman A. Alsageer
Asian Journal of Biology · pp. 15–21 · Published 2 Feb 2021
10.9734/ajob/2021/v11i130132Abstract
Aims: this study aimed to find out the effect of application of 1.5 mg\ml of retinoic acid on chicken development at different stages of neural tube development. Methodology: thirty fertile domestic Gallus gallus eggs were divided into three groups of 10 eggs for each. These groups repeated four time for four different stages HH8, HH10, HH15 and HH18. Retinoic acid (RA) or dimethyl sulphoxide (DEMSO) was injected through the air sac, and the eggs were incubated for another 24 h. Eggs were opened after 24 or 48 h of incubation, and the embryos were evaluated morphologically and histologically. Results: The results of this experiment indicated that, In control group and DEMSO group none exhibited neural tube defects neural tube (NTDs). However group treated with 1.5mg/ml of RA exhibit sever NTDs and malformed at the head, cranial and cardiac regions. Shape of the lumen and spatial arrangement of the cell populations of floor plate and roof plate of neural tube has been changed after RA treatment. Conclusion: Association of excises RA with neural tube defects was demonstrated in the present study on neurulation process during embryogenesis.
References (9)
- 1 TISSUE CHANGES FOLLOWING DEPRIVATION OF FAT-SOLUBLE A VITAMIN [DOI]
- 2 An analysis of the syndrome of malformations induced by maternal vitamin a deficiency. Effects of restoration of vitamin a at various times during gestation [DOI]
- 3 The Briefest of Glances [DOI]
- 4 Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis [DOI]
- 5 Modulation of T Cell and Innate Immune Responses by Retinoic Acid [DOI]
- 6 The distribution of endogenous retinoic acid in the chick embryo: implications for developmental mechanisms [DOI]
- 7 Neurological sequelae of intrauterine warfarin exposure [DOI]
- 8 A comparative study of the effects or retinoic acid given during the critical period for inducing spina bifida in mice and hamsters [DOI]
- 9 CUTANEOUS LESIONS ASSOCIATED WITH A DEFICIENCY IN VITAMIN A IN MAN [DOI]
Cited by 0
No indexed citations yet.
Related research
- Effect of Grape Seed Extract in Minimizing the Harmful Effects of Monosodium Glutamate on the Chicken Embryonic Retina to Show Scientific Miracles In the Holy Quran — shares topic coverage
- In-Vivo Studies of the Angiogenic Potential of Mandur Bhasma — shares topic coverage
- Neuroprotective Effects of Eleveted Dose Vitamin A on the Hippocampus of Adult Male Wistar Rats Exposed to Toxic Doses of Methamphetamine — shares topic coverage
Article metrics
Real usage data collected on this platform.
21
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.