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Research Article Open access CC BY 4.0

The Effect of Methanolic Leaf Extract of Boerhavia diffusa Linn. (Nictaginaceae) on the Activities of Antidiabetic, Anti-inflammatory and Antioxidant Enzymes in Experimental Diabetes

Mama Sirou Amidou Ibrahima, Attakpa Sèlidji Eugène, Béhanzin Gbèssohélè Justin, Amoussa Abdou Madjid, Sangaré Maxime Machioud, Akotegnon Rodrigue, Guinnin Félix, Lagnika Latifou, Sezan Alphonse, Baba-Moussa Lamine, Bialli Seri, Naim Akhtar Khan

Journal of Pharmaceutical Research International · pp. 1–25 · Published 8 Dec 2018

10.9734/JPRI/2018/45640

Abstract

Diabetic therapeutic potentiality of methanol extract of stem leaves of Boerhavia diffusa was investigated following in-vivo study models in streptozotocin-induced diabetic rat. Methanol extract of stem leaves of Boerhavia diffusa exerted the glucose lowering effect an increase in serum insulin level on 28st day of postadministration. In addition to a higher expression of insulin receptor A. The extract treatment or glibenclamide for 28 days significantly (p<0.05) reduced HbA1c. Boerhavia diffusa L. or glibenclamide for 28 days show no damaging effect on red blood count and hemoglobin when compared to the control group.  Significant (p<0.05) increase in platelet count and white blood cell count was observed in groups treated with Boerhavia diffusa L. and glibenclamide when compared to control group.   Boerhavia diffusa L. and glibenclamide showed significant (P<0.05) decrease in total cholesterol (TC), triglyceride (TG) low density Lipoprotein (LDL), Alanine amino transferase (ALT), Aspartate amino transferase (AST),  Alkaline phosphatase (ALP) and Gamma glutamyl transferase (GGT). Methanol extract of 600 mg/kg b.w had more lowering effect (p<0.05) on TC and TG as opposed to the untreated group. Methanol extract or glibenclamide also modulated significantly (P<0.05) the activities of carbohydrate-metabolising enzymes and Hepatic glycogen content. Boerhavia diffusa or glibenclamide administration up-regulated mRNA expression of Glucose Transporter-2 (Glut2) Boerhavia diffusa or glibenclamide also corrected antioxidant status of diabetic animals in liver. The lipid peroxidation inhibition activity of extracts from Boerhavia diffusa is stronger when compared to the reference antioxidant ascorbic acid. These clearly showed that methanol extract from Boerhavia diffusa has the inhibitory activities of the xanthine oxidase, lipoxygenase and acetylcholinesterase enzyme.

Boerhavia diffusa Linn streptozotocin diabetes mellitus anti-inflammatory activity antioxidant enzymes

References (48)

  1. 1 Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.
  2. 2 Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase [DOI]
  3. 3 The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer [DOI]
  4. 4 Antioxidant Activity and Phenolic Compounds in Selected Herbs [DOI]
  5. 5 THE DETERMINATION OF GLYCOGEN IN LIVER AND MUSCLE BY USE OF ANTHRONE REAGENT [DOI]
  6. 6 Antidiabetic plants and their active constituents [DOI]
  7. 7 Postprandial Hyperglycemia and Diabetes Complications [DOI]
  8. 8 Hypoglycaemia: The limiting factor in the glycaemic management of Type I and Type II Diabetes* [DOI]
  9. 9 The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer [DOI]
  10. 10 The Clinical Information Value of the Glycosylated Hemoglobin Assay [DOI]
  11. 11 Therapeutic Potential of Moringa oleifera Leaves in Chronic Hyperglycemia and Dyslipidemia: A Review [DOI]
  12. 12 Hyperglycemia and Diabetic Kidney Disease: The Case for Transforming Growth Factor–β as a Key Mediator [DOI]
  13. 13 Induction of diabetes by Streptozotocin in rats [DOI]
  14. 14 Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism [DOI]
  15. 15 In vitro and in vivo antioxidant activity of aqueous extract from Choerospondias axillaris fruit [DOI]
  16. 16 Antioxidant, anti-inflammatory and antiproliferative properties of sixteen water plant extracts used in the Limousin countryside as herbal teas [DOI]
  17. 17 Antihyperglycaemic activity of Musa sapientum flowers: effect on lipid peroxidation in alloxan diabetic rats [DOI]
  18. 18 Evaluation of antidiabetic and antioxidant activity of Moringa oleifera in experimental diabetes [DOI]
  19. 19 Inhibitors of 15-Lipoxygenase from Orange Peel [DOI]
  20. 20 Effects of flavonoids on insulin secretion and 45Ca2+ handling in rat islets of Langerhans [DOI]
  21. 21 In vitro and in vivo antioxidant activity of Pinus koraiensis seed extract containing phenolic compounds [DOI]
  22. 22 Role of Moringa oleifera in regulation of diabetes-induced oxidative stress [DOI]
  23. 23 [66] Pyruvate kinase from muscle [DOI]
  24. 24 THE ASSOCIATION OF HEXOKINASE WITH PARTICULATE FRACTIONS OF BRAIN AND OTHER TISSUE HOMOGENATES [DOI]
  25. 25 The oxygen free radical system: from equations through membrane-protein interactions to cardiovascular injury and protection [DOI]
  26. 26 Hepatoprotective activity of Boerhaavia diffusa L. roots — a popular Indian ethnomedicine [DOI]
  27. 27 Anti-angiogenic, antioxidant and xanthine oxidase inhibition activities of the mushroom Phellinus linteus [DOI]
  28. 28 The juice of fresh leaves of Boerhaavia diffusa L. (Nyctaginaceae) markedly reduces pain in mice [DOI]
  29. 29 Effect of guava (Psidium guajava Linn.) leaf soluble solids on glucose metabolism in type 2 diabetic rats [DOI]
  30. 30 Glucose Metabolism in Mice Lacking Muscle Glycogen Synthase [DOI]
  31. 31 Glycogen synthesis by hepatocytes from diabetic rats [DOI]
  32. 32 Constituents of the Roots of Boerhaavia diffusa L. III. Identification of Ca2+ Channel Antagonistic Compound from the Methanol Extract. [DOI]
  33. 33 A study on antioxidant, free radical scavenging, anti-inflammatory and hepatoprotective actions of Aegiceras corniculatum (stem) extracts [DOI]
  34. 34 Therapeutic effect of ferulic acid, an ethereal fraction of ethanolic of seed of Syzygium cumini against streptozotocin-induced diabetes in male rat [DOI]
  35. 35 Effects of Fluoxetine on the Oxidative Status of Peripheral Blood Leucocytes of Restraint-Stressed Mice [DOI]
  36. 36 Moringa oleifera Lam.: panacea to several maladies.
  37. 37 Antihyperglycemic Effect on Chronic Administration of Butanol Fraction of Ethanol Extract of Moringa Stenopetala Leaves in Alloxan Induced Diabetic Mice [DOI]
  38. 38 ChemInform Abstract: Punarnavoside: A New Antifibrinolytic Agent from Boerhaavia diffusa Linn. [DOI]
  39. 39 Antioxidant properties and xanthine oxidase inhibitory effects of Tamus communis L. root extracts [DOI]
  40. 40 Maternal and fetal indicators of oxidative stress in various obstetric complications [DOI]
  41. 41 Investigations on Indian medicinal plants.
  42. 42 Erythrocyte changes in canine diabetes mellitus: in vitro effects of hyperglycaemia and ketoacidosis [DOI]
  43. 43 Antihyperglycaemic, antioxidative activities of a formulated polyherbal drug MTEC (Modified) in streptozotocin-induced diabetic rat. [DOI]
  44. 44 Inhibition of COXs and 5-LOX and activation of PPARs by Australian Clematis species (Ranunculaceae) [DOI]
  45. 45 Gongronema latifolium Crude Leaf Extract Reverses Alterations in Haematological Indices and Weight-loss in Diabetic Rats [DOI]
  46. 46 XANTHINE OXIDASE INHIBITORY AND ANTIHYPERURICEMIC ACTIVITIES OF ANREDERA CORDIFOLIA (TEN) STEENIS, SONCHUS ARVENSIS L, AND ITS COMBINATION
  47. 47 Post-irradiation free radical generation: evidence from the conversion of xanthine dehydrogenase into xanthine oxidase.
  48. 48 The glycolytic enzymes of guinea-pig lung in experimental bagassosis [DOI]

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