Skip to content
Research Article Open access CC BY 4.0

The Effect of Gongronema latifolium Leaf Extract on Blood Biochemical Assay in Diabetic Rats

Effiong Grace Sylvester, Eshiet Unyime Israel, Ajibola Dorcas Olajumoke

Journal of Scientific Research and Reports · pp. 514–522 · Published 10 Apr 2015

10.9734/JSRR/2015/15891

Abstract

Gongronema latifolium (GL) is used extensively in the indigenous system of medicine as an anti-diabetic agent. Hypoglycemic and hypolipidemic activities of Gongronema latifolium extract in Type 2 diabetic rat models were evaluated using standard analytical methods while Blood was collected on every 3 days through the rat’s tail vein for glucose estimation using One Touch Glucometer. Blood glucose in the diabetic animals decreased significantly (P=.05) from initial by 66.34% upon treatment with Gongronema latifolium. Diabetes induction caused significant increases (P=.05) in total cholesterol (TC) with 54.42% and low density lipoprotein (LDL) with 55.0% compared to the normal control (NC), while treatment with extracts of Gongronema latifolium significantly decreased (P=.05) these by (58.70% TC) and (71.70% LDL) respectively. Also the amino transferases (ALT and AST) parameters activities which increased by 66.83% and 72.87% in the diabetic control (DC) rats became reduced upon treatment with Gongronema latifolium. Thus the plant extract was capable of ameliorating hyperglycemia and hyperlipidemia in streptozotocin-induced diabetic rats and could be a potential source for isolation of new orally active agent(s) for anti-diabetic therapy.

Aminotransferases blood glucose diabetes mellitus Gongronema latifolium hyperglycemia hyperlipidemia.

References (27)

  1. 1 Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge [DOI]
  2. 2 A new approach to practical acute toxicity testing [DOI]
  3. 3 Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? [DOI]
  4. 4 The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas [DOI]
  5. 5 Systematic Review of Herbs and Dietary Supplements for Glycemic Control in Diabetes [DOI]
  6. 6 Regulation of Hepatic Glucose Uptake and Storage In Vivo [DOI]
  7. 7 The effect ofGongronema latifolium extracts on serum lipid profile and oxidative stress in hepatocytes of diabetic rats [DOI]
  8. 8 Antihyperglycemic effect of aqueous and ethanolic extracts of Gongronema latifolium leaves on glucose and glycogen metabolism in livers of normal and streptozotocin-induced diabetic rats [DOI]
  9. 9 EVALUATION OF PEPPER (CAPSICUM ANNUUM) FOR MANAGEMENT OF DIABETES AND HYPERTENSION [DOI]
  10. 10 Antioxidant effects of Gongronema latifolium in hepatocytes of rat models of non-insulin dependent diabetes mellitus [DOI]
  11. 11 In vitro antibacterial activity and acute toxicity studies of aqueous-methanol extract of Sida rhombifolia Linn. (Malvaceae) [DOI]
  12. 12 The Antidiabetic Efficacy of Combined Extracts from Two Continental Plants: Azadirachta indica (A. Juss) (Neem) and Vernonia amygdalina (Del.) (African Bitter Leaf) [DOI]
  13. 13 [Liver function tests].
  14. 14 Medicinal Herbs Used for Managing Some Common Ailments among Esan People of Edo State, Nigeria [DOI]
  15. 15 Comparative chemical composition of leaves of some antidiabetic medicinal plants: Azadirachta indica, Vernonia amygdalina and Gongronema latifolium [DOI]
  16. 16 Biological Complementary Therapies: A Focus on Botanical Products in Diabetes [DOI]
  17. 17 In Vitro Inhibitory Effects of Cyandin-3-rutinoside on Pancreatic α-Amylase and Its Combined Effect with Acarbose [DOI]
  18. 18 Effect of Gongronema latifolium crude leaf extract on some cardiac enzymes of alloxan-induced diabetic rats
  19. 19 On the mechanism of hepatic transendothelial passage of large liposomes [DOI]
  20. 20 Hepatotoxicity of carbon tetrachloride: protective effect of Gongronema latifolium.
  21. 21 Vernonia amygdalina Del: A potential prophylactic anti-diabetic agent in lipid complication [DOI]
  22. 22 Effect of Gongronema latifolium Leaf Extract on some Liver Enzymes and Protein Levels in Diabetic and non Diabetic Rats
  23. 23 Extract of Vernonia Amygdalina Del. (African Bitter Leaf) Can Reverse Pancreatic Cellular Lesion after Alloxan Damage in the Rat
  24. 24 Antidiabetic Effect of Nauclea latifolia Leaf Ethanolic Extract in Streptozotocin-induced Diabetic Rats
  25. 25 Effect of rioprostil and colchicine on CC14-acute liver damage in rats. Relationship with plasma membrane lipids [DOI]
  26. 26 Comparative Study of Lipid and Glycemic Effects of Pioglitazone, Rosiglitazone with Glibenclamide in Patients with Type 2 Diabetes and Dyslipidemia
  27. 27 International Diabetes Federation (IDF) [DOI]

Cited by 17

Screening for Minerals and Anti-minerals Composition of Gongronema latifolium (Utasi) Leaf

Usoro Etesin, Ibanga Isaac, Edidiong Ikpe, Ufikairom G. Isotuk, Asuquo Unyime Joseph · Asian Journal of Chemical Sciences · 2018

Ethanolic extract of Mucuna pruriens leaves ameliorates carbon tetrachloride and rifampicin-induced hepatotoxicity and nephrotoxicity in wistar albino rat

Temidayo Ogunmoyole, Ayomide Micheal Ola-Awe, Omotola Grace Fatile · BMC Complementary Medicine and Therapies · 2021

Ameliorative Potential of Azadirachta indica and Gongronema latifolium on Plasmodium-induced Gonadotoxicity in Swiss Mice

Department of Human Anatomy, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria., Alice J. Peter, Innocent A. Edagha · International Journal of Anatomy and Research · 2023

Comparative hypoglycemic potentials and phytochemical profiles of 12 common leafy culinary vegetables consumed in Nsukka, Southeastern Nigeria

Patrick Emeka Aba, Ifeanyi Ronald Udechukwu · Journal of Basic and Clinical Physiology and Pharmacology · 2018

Safety assessment of the ethanolic extract of Gongronema latifolium Benth. leaves: a 90-day oral toxicity study in Sprague Dawley rats

Bassel Al-Hindi, Nor Adlin Yusoff, Mariam Ahmad · BMC Complementary and Alternative Medicine · 2019

Evaluation of the Hepato-Renal Protective Activity of Ethanolic Mucuna pruriens Leaf Extract in Drug- and Chemical-Induced Toxicity in Wistar Rats

Mariela Soledad Rivas, Constanza Beatriz Munoz · Journal of Medical Sciences and Interdisciplinary Research · 2025

Showing 8 of 17 known citations — external sources report more than can currently be individually listed.

Article metrics

Real usage data collected on this platform.

68

Page views

0

PDF downloads

32

Outbound clicks

17

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.