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Research Article Open access CC BY 4.0

The Effect of Ginger on the Invasion and Migration of Glioma Cells

Manar Zraikat, Munir Gharaibeh, Tasneem Alshelleh

European Journal of Medicinal Plants · pp. 38–43 · Published 3 Jul 2020

10.9734/ejmp/2020/v31i1030279

Abstract

Background: This work studies the effect of different concentrations of soaked ginger on the ability of the U87 glioma cells to invade collagen in a three dimension (3 D) invasion model and compare it with its effect on the ability of the same cell line to migrate in two-dimension (2 D) scratch assay. Methods: The hanging drop spheroids in 3D invasion assay were used to investigate the in invasion of the U87 cells. The 2D scratch assay was used to investigate the migration of the same cell line. Results: Gradual effect of the soaked ginger was noticed on the inhibition of the invasion of U87 in collagen and on the inhibition of the migration of the same cell line in scratch assay. Conclusion: The results in this article are promising and encourage further studies to investigate the effect of ginger active ingredients on tumour progression.

Invasion cancer migration assay

References (15)

  1. 1 [6]-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells [DOI]
  2. 2 Update on the Chemopreventive Effects of Ginger and its Phytochemicals [DOI]
  3. 3 Multiple mechanisms are involved in 6‐gingerol‐induced cell growth arrest and apoptosis in human colorectal cancer cells [DOI]
  4. 4 Increased Growth Inhibitory Effects on Human Cancer Cells and Anti-inflammatory Potency of Shogaols from Zingiber officinale Relative to Gingerols [DOI]
  5. 5 6-Gingerol inhibits ROS and iNOS through the suppression of PKC-α and NF-κB pathways in lipopolysaccharide-stimulated mouse macrophages [DOI]
  6. 6 Anti‐invasion effects of 6‐shogaol and 6‐gingerol, two active components in ginger, on human hepatocarcinoma cells [DOI]
  7. 7 Cytotoxic components from the dried rhizomes of Zingiber officinaleRoscoe [DOI]
  8. 8 Nuclear factor-kappaB activity correlates with growth, angiogenesis, and metastasis of human melanoma cells in nude mice.
  9. 9 [6]-Shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2 [DOI]
  10. 10 Molecular mechanism inhibiting human hepatocarcinoma cell invasion by 6‐shogaol and 6‐gingerol [DOI]
  11. 11 Ginger's (Zingiber officinale Roscoe) inhibition of rat colonic adenocarcinoma cells proliferation and angiogenesis in vitro [DOI]
  12. 12 10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity [DOI]
  13. 13 6-Gingerol inhibits osteosarcoma cell proliferation through apoptosis and AMPK activation [DOI]
  14. 14 Evaluation of the antioxidant impact of ginger-based kombucha on the murine breast cancer model [DOI]
  15. 15 Statins and Peripheral Arterial Disease: Effects on Claudication, Disease Progression, and Prevention of Cardiovascular Events [DOI]

Cited by 2

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Ilkay Irem Ozbek, M. Aktas, H. Saybaşılı · Phytochemical Analysis · 2026

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