The Correlation of Promoter Polymorphism and Expression of Androgen Receptor Gene with Hypospadia Incidence
Yevri Zulfiqar, Yanwirasti ., Jamsari ., Irfan Wahyudi
Journal of Advances in Medical and Pharmaceutical Sciences · pp. 1–9 · Published 9 Jan 2018
10.9734/JAMPS/2017/34294Abstract
Introduction: Hypospadia is one of the most common congenital abnormalities, yet the exact cause remains unknown. Androgen Receptor (AR) is suspected to cause hypospadias. Methods: As many as 49 post-operative prepuces of hypospadia patients and 49 normal prepuces from elective circumcision were recruited. Materials of this study were prepuces of hypospadia patients and normal children’s prepuces. The prepuces were collected from residual tissue of the patients who underwent operation. The operation was a standard procedure done by urologist in the hospital. Utilization of residual prepuces as study material could be an ethical issue. Therefore, explanation to patient’s parents about purpose, advantage, and disadvantage of the study was necessary. All cost needed to examine AR gene polymorphism and expression was borne by authors. Confidentiality of the study was guaranteed. Results: The result of this study showed no AR polymorphisms in experimental and control group. AR gene over-expression was found in experimental group, and it was statistically significant (p = 0.001). From this study, we found that AR gene over-expression was correlated with hypospadia incidence.
References (9)
- 1 Association of Long Polyglycine Tracts (GGN Repeats) in Exon 1 of the Androgen Receptor Gene With Cryptorchidism and Penile Hypospadias in Iranian Patients [DOI]
- 2 The Stress Response Mediator ATF3 Represses Androgen Signaling by Binding the Androgen Receptor [DOI]
- 3 Hypospadias Risk and Polymorphism in SRD5A2 and CYP17 Genes: Case-Control Study Among Indian Children [DOI]
- 4 Studies of a co-chaperone of the androgen receptor, FKBP52, as candidate for hypospadias [DOI]
- 5 Quantitative measurement of the androgen receptor in prepuces of boys with and without hypospadias [DOI]
- 6 Androgen receptor is overexpressed in boys with severe hypospadias, and ZEB1 regulates androgen receptor expression in human foreskin cells [DOI]
- 7 The CAG repeat polymorphism in the Androgen receptor gene modifies the risk for hypospadias in Caucasians [DOI]
- 8 Activating transcription factor 3 is not up-regulated in hypospadias patients in Japan [DOI]
- 9 New single nucleotide variation in the promoter region of androgen receptor (AR) gene in hypospadic patients.
Cited by 0
No indexed citations yet.
Related research
- Transforming Transcriptomics: The Impact of RNA Sequencing Technology — shares topic coverage
- Lifestyle Changes of Type 2 Diabetes Subjects Expressing CDKN2A in Some Tribes in Nigeria — shares topic coverage
- Molecular Response of Plants to Drought, Cold and Heat Stress - A Review — shares topic coverage
- Different Expression of Segmentally Duplicated ZmMPK6-1 and ZmMPK6-2 Paralogues in Maize — shares topic coverage
- The Protective Effect of Pomegranate (Punica granatum) against Oxidative Stress and Nephropathy Induced by Diabetes in Male Rats: A Biochemical, Molecular and Histopathological Study — shares topic coverage
Article metrics
Real usage data collected on this platform.
60
Page views
0
PDF downloads
22
Outbound clicks
0
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.