Tetrapleura tetraptera (Schum and Thonn) Taub Fruit Extract Impairs Reproductive Hormones and Fertility Parameters in Female Experimental Rats
Ologhaguo Macstephen Adienbo, Ogechi Stephanie Ezeala
Journal of Advances in Medical and Pharmaceutical Sciences · pp. 27–33 · Published 24 Apr 2021
10.9734/jamps/2021/v23i330225Abstract
Aim: The increasing rate of infertility in humans has necessitated the need to assess commonly used medicinal plants to ascertain their effects on reproductive functions. The aim of this study was to determine the effects of tetrapleura tetraptera fruit extract on reproductive hormones and fertility in females. Methods: A total of seventy two (72) adult female wistar rats weighing 160-180 g were randomly assigned into four groups of 18 animals each. Group1 (control) was administered distilled water, groups II, III and lV were daily treated with the extract at doses of 75, 150 and 300 mg/kg body weight, respectively, orally for 28 days. Thereafter, 6 rats from each group were sacrificed during oestrous phase and serum used for analyses of reproductive hormones; while remaining 12 females from each group were each cohabited with males (2:1), sacrificed at gestational age16 and fertility parameters were determined. Results: The results show that in the test groups, there was significant (P < 0.05 ) reduction in the levels of FSH, LH and Estrogen, with a significant (P < 0.05 ) increase in progesterone, when compared with the control. Also, the number of pregnant female rats, number of foetuses, and fertility index significantly (P < 0.05 ) increased in the test animals, compared with the control. Conclusion: We concluded that Tetrapleura. tetraptera fruit extract impairs reproductive hormones and fertility parameters in female rats, and therefore should be consumed with caution.
References (6)
- 1 Foods of Plant Origin
- 2 Effects of some traditional plant extracts on rat oestrous cycle compared with Clomid [DOI]
- 3 Anticonvulsant activity of the volatile oil from the fruit of tEtrapleura tetraptera [DOI]
- 4 Identification and preliminary phytochemical analysis of herbs that can arrest threatened miscarriage in Orba and Nsukka towns of Enugu State [DOI]
- 5 Antifertility effect of Piper betle Linn. extract on ovary and testis of albino rats.
- 6 EVALUATION OF ANTI-FERTILITY ACTIVITY OF ETHANOL EXTRACT OF CYNOGLOSSUM ZEYLANICUM (VEHL EX HORNEM) THUMB. EX LEHM (BORAGINACEAE) WHOLE PLANT ON MALE ALBINO RATS
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