Skip to content
Research Article Open access CC BY 4.0

Takotsubo Following Severe Anaphylactic Reaction during Anesthesia Induction

OBEIDAT Saleh, Boucetta A, Siyam H, Altimimi A, Arous S, Bennouna M, Drighil A, Habbal R

Cardiology and Angiology: An International Journal · pp. 193–199 · Published 26 Nov 2024

10.9734/ca/2024/v13i4459

Abstract

Introduction: Takotsubo cardiomyopathy (apical ballooning or broken heart syndrome) is a reversible left ventricular dysfunction due to apical asynergy that occurs typically after sudden emotional stress in a subject without coronary disease. Anaphylaxis is a severe, life-threatening, generalized hypersensitivity reaction, most often starting with urticaria and/or angioedema, that may involve cardiovascular and respiratory systems. Cardiovascular symptoms, including hypotension, cardiac arrhythmia and chest pain, are presumably linked to cardiac mast cell mediator release. Case Report: We describe the case of a woman who experienced a profound reversible cardiomyopathy with typical features of Takotsubo's syndrome during an anaphylactic reaction. Conclusion: Exposure to catecholamines and beta-receptor agonists used routinely during procedures and diagnostic tests can precipitate all the features of stress cardiomyopathy, including cardiac isoenzyme elevation and rapidly reversible cardiac dysfunction. These observations strongly implicate excessive sympathetic stimulation as central to the pathogenesis of this unique syndrome.

Takotsubo syndrome ballooning apical anaphylaxis catecholamines case report

References (15)

  1. 1 International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology [DOI]
  2. 2 Takotsubo Syndrome: Pathophysiology, Emerging Concepts, and Clinical Implications [DOI]
  3. 3 Pathophysiology of Takotsubo Syndrome [DOI]
  4. 4 Epidemiology and pathophysiology of Takotsubo syndrome [DOI]
  5. 5 Tako-tsubo-like left ventricular dysfunction due to multivessel coronary spasm
  6. 6 Mechanisms of stress (Takotsubo) cardiomyopathy [DOI]
  7. 7 Epidemiology, Pathophysiology, Diagnosis, and Principles of Management of Takotsubo Cardiomyopathy: A Review [DOI]
  8. 8 Perioperative Takotsubo Cardiomyopathy: A Systematic Review of Published Cases [DOI]
  9. 9 Takotsubo cardiomyopathy and its relevance to anesthesiology: a narrative review [DOI]
  10. 10 Attack the ATAK; A Challenging Contemporary Complex: Pathophysiologic, Therapeutic, and Preventive Considerations [DOI]
  11. 11 Takotsubo cardiomyopathy associated with Kounis syndrome: A clinical case of the “ATAK complex” [DOI]
  12. 12 Takotsubo cardiomyopathy and its variants: a case series and literature review [DOI]
  13. 13 Is Adrenaline Always the First Choice Therapy of Anaphylaxis? An Allergist-cardiologist Interdisciplinary Point of View [DOI]
  14. 14 Kounis and Takotsubo, Two Syndromes Bound by Adrenaline: The “ATAK” Complex [DOI]
  15. 15 A case of takotsubo cardiomyopathy in a patient with anaphylaxis treated with epinephrine [DOI]

Cited by 1

COVID-19 Vaccine-Related Cardiovascular Long-Term Complications

Ghaith Mohammed · Afro-Asian Journal of Scientific Research (AAJSR) · 2025

Related research

Article metrics

Real usage data collected on this platform.

63

Page views

0

PDF downloads

43

Outbound clicks

1

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.