Skip to content
Research Article Open access CC BY 3.0

Systematic Evaluation on Antioxidant of Magnolol in vitro

Xican Li, Chan Chen

International Research Journal of Pure and Applied Chemistry · pp. 68–76 · Published 13 Feb 2012

10.9734/IRJPAC/2012/628

Abstract

We systematically evaluated in vitro the antioxidant activity of magnolol, a natural phenolic phenylpropanoid, using DPPH (1, 1-Diphenyl-2-picrylhydrazyl radical), ABTS [2, 2′-Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)], Ferric ions (Fe3+) reducing power, superoxide anion and hydroxyl radical-scavenging. In all assays, magnolol and positive controls exhibited effective antioxidant ability. The IC50 values of magnolol were calculated as 25.92, 0.85, 737.56, 29.97, 153.46 μg/mL, respectively, for DPPH, ABTS, Fe3+ reducing power, superoxide anion and hydroxyl radical-scavenging. In these five assays, the IC50 values of Trolox were respectively calculated as 5.08, 2.02, 58.92, 160.26, 62.69 μg/mL, while the IC50 values of BHT were respectively 4.17, 1.76, 75.83, 43.31, 202.64 μg/mL. Furthermore, as DPPH and ABTS assays were conducted in organic solutions, while the other assays were finished in aqueous solutions, magnolol is therefore regarded as an effective antioxidant in vitro in both lipid and aqueous media. Its various protective effects may be attributed to the antioxidant. The fact that magnolol could effectively scavenge both DPPH• and ABTS+• suggested it may exert antioxidant action in vitro by donating hydrogen atom (H•) or electron (e).  

Systematic evaluation magnolol antioxidant radical-scavenging reducing power in vitro

References (11)

  1. 1 Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase [DOI]
  2. 2 In vivo total antioxidant capacity: comparison of different analytical methods1 [DOI]
  3. 3 Neuroprotective activity of honokiol and magnolol in cerebellar granule cell damage [DOI]
  4. 4 Antioxidant activity of Magnolol, honokiol, and related phenolic compounds [DOI]
  5. 5 Free radical scavenging and total phenolic contents from methanolic extracts of Ulmus davidiana [DOI]
  6. 6 Antioxidative and hepatoprotective effects of magnolol on acetaminophen-induced liver damage in rats [DOI]
  7. 7 Comparison of antioxidant abilities of magnolol and honokiol to scavenge radicals and to protect DNA [DOI]
  8. 8 Evaluation of Antioxidant Activity of Isoferulic Acid in vitro [DOI]
  9. 9 Effects of electron-withdrawing substituents on DPPH radical scavenging reactions of protocatechuic acid and its analogues in alcoholic solvents [DOI]
  10. 10 Effect of Magnolol onin VitroMitochondrial Lipid Peroxidation and Isolated Cold-Preserved Warm-Reperfused Rat Livers [DOI]
  11. 11 Neuroprotective effect of magnolol in the hippocampus of senescence-accelerated mice (SAMP1) [DOI]

Cited by 31

Magnolol additive as a replacer of antibiotic enhances the growth performance of Linwu ducks

Qian Lin, Jianfei Zhao, Kun Xie · Animal Nutrition · 2017

In Vitro Antioxidant Activity and Total Phenolic Content of Root Extracts from Phragmanthera glaucocarpa (Peyr.) Balle

Nelson António Freitas Fernandes, Laura Isabel Nave Canelo, Rosalina da Conceição dos Santos Mata · Jundishapur Journal of Natural Pharmaceutical Products · 2018

Antioxidant activity and mechanism of Rhizoma Cimicifugae

Xican Li, Jing Lin, Yaoxiang Gao · Chemistry Central Journal · 2012

Effect of different plant growth regulators on callus and adventitious shoots induction, polysaccharides accumulation and antioxidant activity of Rhodiola dumulosa

Xu Lu, Liangdan Fei, Yi Li · Chinese Herbal Medicines · 2023

Chemistry Study on Protective Effect against·OH-induced DNA Damage and Antioxidant Mechanism of Cortex Magnoliae Officinalis

Xican Li, Qian Fang, Jing Lin · Bulletin of the Korean Chemical Society · 2014

Impact of the drying mode and ageing time on sugar profiles and antioxidant capacity of electro-activated sweet whey

Muhammad-Javeed Akhtar, Martin Mondor, Mohammed Aïder · International Dairy Journal · 2018

Synthesis, characterization and antioxidant evaluation of metal complexes derived from a dianil ligand with a flexible linkage: anomalous magnetic behavior of the nickel complex

Amel F. Elhusseiny, Hammed H. A. M Hassan, Hend Hussien · Transition Metal Chemistry · 2015

Novel Mannich bases of α- and γ-mangostins: Synthesis and evaluation of antioxidant and membrane-protective activity

Evgeny V. Buravlev, Oksana G. Shevchenko, Aleksei A. Anisimov · European Journal of Medicinal Chemistry · 2018

Magnolol protects Saccharomyces cerevisiae antioxidant-deficient mutants from oxidative stress and extends yeast chronological life span

Subasri Subramaniyan, Phaniendra Alugoju, Sudharshan SJ · FEMS Microbiology Letters · 2019

Magnolol additive improves carcass and meat quality ofLinwuducks by modulating antioxidative status

Qian Lin, Simin Peng, Yinghui Li · Animal Science Journal · 2019

Showing 12 of 31 known citations — external sources report more than can currently be individually listed.

Related research

Article metrics

Real usage data collected on this platform.

107

Page views

0

PDF downloads

36

Outbound clicks

31

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.