Synthesis, Spectroscopic Characterization, Antioxidant Properties and Antimicrobial Activity of Transition Metal Complexes from Novel Schiff Base

Abstract

Benzoylpyridine and nitro benzoic acid hydrazides were used to examine novel Schiff base Co(II), Mn(II), Fe(II), and Cu(II) complexes. Elemental analysis, molar conductance, magnetic measurements and other methods that like FT-IR, UV–Vis and 1H NMR studies have been used to deduce the nature of bonding and structure of these complexes. These studies revealed that the Co(II), Mn(II), Fe(II) and Cu(II) coordinated by four donor atoms in all the complexes. Free radical scavenging activity was determined according to the elimination of radicals from 2,2-diphenyl-1-picrylhydrazyl (DPPH). These compounds were compared to known antibiotics ciprofloxacin and fluconazole in their ability to inhibit the growth of pathogenic bacteria Bacillus subtilis (as gramme positive bacteria), Pseudomonas sp. (as gramme negative bacteria), and fungus Rhizoctonia sp., Alternaria sp., and Fusarium oxysporum. As an antibacterial and antioxidant agent, the complexes are more effective than the ligand. The copper (II) complex has been discovered to be the most effective antibacterial and antioxidant agent.