Synthesis, Characterization and Preliminary Biological Evaluation of New 3 and 4-nitro Isoindoline-1, 3-dione/phthalimide Analogues
Sharad Sankhe, Nitesh Chindarkar
Journal of Pharmaceutical Research International · pp. 20–27 · Published 1 Mar 2021
10.9734/jpri/2021/v33i631186Abstract
Aims: To synthesize new nitroisoindoline-1,3-diones analogues and evaluate their preliminary biological activities Methodology: New isoindoline-1,3-diones analogues were synthesized by coupling phthalic anhydride derivatives with appropriate aromatic amines. Newly synthesized heterocyclic compounds were evaluated for their in vitro antibacterial activity against gram-positive bacterial strains and gram-negative bacterial strains. They were also tested for their in vitro antifungal activity against fungi strains. Determination of the preliminary antibacterial and antifungal activity were investigated using agar-dilution method. The structures of newly synthesized analogues were elucidated by 1H and 13C-NMR techniques. Results: Bioassay indicated that some of the newly synthesized isoindoline-1,3-dione analogues shows moderate biological activities. Conclusion: Newly synthesized analogues can be used as antibacterial or antifungal agents on modifications.
Cited by 2
Hatem A. Abuelizz, Ahmed H. Bakheit, Mohamed Marzouk · Molecules · 2022
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