Skip to content
Research Article Open access CC BY 3.0

Synthesis and Evaluation of Analgesic and Anti-inflammatory Activities of Most Active Free Radical Scavenging Derivatives of Mangiferin

S. Mahendran, S. Badami, S. Ravi, B. S. Thippeswamy, V. P. Veerapur

Current Journal of Applied Science and Technology · pp. 4959–4973 · Published 30 Sep 2014

10.9734/BJAST/2014/12745

Abstract

In the present study, structural modification of mangiferin was carried out for structure activity relationship studies. One new compound and three known derivatives were prepared from mangiferin. All these compounds were synthesized and purified by standard procedures, identified by using physical and spectral (IR, 1H NMR, 13C NMR and MS) properties. The synthesized mangiferin derivatives were tested for In vitro antioxidant properties. Benzyl and methyl substituted mangiferin showed poor antioxidant activity than mangiferin. However, mangiferin derivatives substituted with acetyl and benzoyl groups were showed potent antioxidant activity than mangiferin in lipid peroxidation, p-NDA, deoxyribose and alkaline DMSO methods. But both the compounds failed to show potent analgesic and anti-inflammatory activities. In all these methods, standard drugs showed better activity than mangiferin and its derivatives.

Mangiferin derivatives antioxidant analgesic anti-inflammatory.

References (28)

  1. 1 Glossary of Indian Medicinal Plants
  2. 2 Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? [DOI]
  3. 3 Handbook of Experimental Pharmacology. [DOI]
  4. 4 Reactive oxygen species: role in the development of cancer and various chronic conditions. [DOI]
  5. 5 Oxygen radical scavenging activity of curcumin [DOI]
  6. 6 The Role of Glia in the Spinal Cord in Neuropathic and Inflammatory Pain [DOI]
  7. 7 [46] Antioxidant action of Ginkgo biloba extract EGb 761 [DOI]
  8. 8 Antioxidant Action of Ginkgo Biloba Extract (EGB 761) [DOI]
  9. 9 Antioxidant activities of flavidin in different in vitro model systems [DOI]
  10. 10 Mangiferin protects the streptozotocin-induced oxidative damage to cardiac and renal tissues in rats [DOI]
  11. 11 In vitro effects of mangiferin on superoxide concentrations and expression of the inducible nitric oxide synthase, tumour necrosis factor-α and transforming growth factor-β genes [DOI]
  12. 12 Antioxidant Effects of Water Extracts from Barley (Hordeum vulgare L.) Prepared under Different Roasting Temperatures [DOI]
  13. 13 Modulation of rat macrophage function by the Mangifera indica L. extracts Vimang and mangiferin [DOI]
  14. 14 Mechanism of Antioxidant Action of Pueraria Glycoside(PG)-1 (an Isoflavonoid) and Mangiferin (a Xanthonoid). [DOI]
  15. 15 Iron complexing activity of mangiferin, a naturally occurring glucosylxanthone, inhibits mitochondrial lipid peroxidation induced by Fe2+-citrate [DOI]
  16. 16 Antioxidant Benzoylated Flavan-3-ol Glycoside from Celastrus orbiculatus [DOI]
  17. 17 A tail withdrawal procedure for assessing analgesic activity in rhesus monkeys [DOI]
  18. 18 [Antiviral activity of mangiferin against herpes simplex virus type 2 in vitro].
  19. 19 Identification and evaluation of antioxidant, analgesic/anti-inflammatory activity of the most active ninhydrin–phenol adducts synthesized [DOI]
  20. 20 Evaluation of antibacterial activity of Mangifera indica on anaerobic dental microglora based on in vivo studies.
  21. 21 Protective Role of Mangiferin against Benzo(a)pyrene Induced Lung Carcinogenesis in Experimental Animals [DOI]
  22. 22 Constitution of mangiferin [DOI]
  23. 23 PhCOCl-Py/Basic Alumina as a Versatile Reagent for Benzoylation in Solvent-Free Conditions [DOI]
  24. 24 Antioxidant Action of Ginkgo biloba Extract. [DOI]
  25. 25 Indigenous Drugs of India: Their Medical and Economic Aspects. [DOI]
  26. 26 Pulse radiolysis studies of mangiferin: A C-glycosyl xanthone isolated from Mangifera indica [DOI]
  27. 27 Synthesis of mangiferin derivates and study their potent PTP1B inhibitory activity [DOI]
  28. 28 Corrigendum to “Identification and evaluation of antioxidant, analgesic/anti-inflammatory activity of the most active ninhydrin–phenol adducts synthesized” [Bioorg. Med. Chem. 14 (2006) 7113–7120] [DOI]

Cited by 9

Bio‐ and chemical syntheses of mangiferin and congeners

Teddy Stephen Ehianeta, Stéphane Laval, Biao Yu · BioFactors · 2016

Synthetic Chiral Derivatives of Xanthones: Biological Activities and Enantioselectivity Studies

Carla Fernandes, Maria Letícia Carraro, João Ribeiro · Molecules · 2019

Showing 3 of 9 known citations — external sources report more than can currently be individually listed.

Article metrics

Real usage data collected on this platform.

47

Page views

0

PDF downloads

34

Outbound clicks

9

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.