Synthesis and Cytotoxicity of Some New Substituted Hydronaphthalene Derivatives
Mogedda E Haiba, Ebtehal S Al-Abdullah, Noha Mohamed Hilmy
Chemical Science International Journal · pp. 203–220 · Published 3 May 2013
10.9734/ACSJ/2013/3452Abstract
A new series of hydronaphthalene derivatives incorporated into or fused to different five or six membered nitrogen, oxygen, sulpher, heretrocyclic, S- glycosidic or N-glycosidic moieties and other related products had been described. The hydrazine derivative 2 was coupled with bromo-sugar to achieve N-glycosides in presence of acidic medium while, the products 4 and 15 were coupled with different bromo sugar achieving S-glycosides in presence of a basic medium. Moreover, other derivatives carrying different biologically active side chains and hetero cyclic substituents were synthesized starting with 6-methoxy-1-tetralone 1. Also, the X-ray data of compound 13c was studied. The cytotoxicity of some of the newly synthesized compounds was studied to evaluate their in-vitro inhibitory effects against cellular proliferation in human cultured breast carcinoma cell lines. It has been found that the chalcone derivatives 13a-c and their cyclized thiopyrimidine analogues 14a, b appeared to be potent breast carcinoma growth inhibitors comparing to Doxorubicin.
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Cited by 3
Gefei Li, Masato Noguchi, Haruka Kashiwagura · Tetrahedron Letters · 2016
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Casey J. Maguire, Graham J. Carlson, Jacob W. Ford · MedChemComm · 2019
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