Stability Constant and Thermodynamic Parameters Determination of A Semi-synthetic Penicillin Derivative with Various Bivalent Metal Ions (Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Sn2+, Hg2+ and Pb2+): A Potentiometric Study
International Research Journal of Pure and Applied Chemistry · pp. 441–448 · Published 28 Aug 2013
10.9734/IRJPAC/2014/5077Abstract
This present work is a report on the stability constant values of a worthy antibiotic, Ampicillin Trihydrate; D[-]-α-aminobenzyl penicillin; ABP; a semi-synthetic derivative of penicillin with various biologically vital bivalent metal ions (Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Sn2+, Hg2+ and Pb2+) recorded in water-ethanol medium 50% V/V at three different temperatures (298K, 308K, 318K)maintaining ionic strength at 0.1M KNO3. The effect of temperature was also studied and the corresponding thermodynamic functions ∆Gº, ∆Hº and ∆Sº were calculated and discussed. It is significant to study the stability constants of drugs with these metal ions as they may already be present in human body. The proton-ligand and metal-ligand stability constants were determined by Calvin-Bjerrum pH titration techniques as modified by Irving and Rossitti. This analysis was carried out in order to determine the pk1H and log k1, values at 298 K, 308 K and 318 K. The metal to ligand mole ratio was maintained at 1:5 in order to fulfil the maximum coordination number of metal ion. The titrations were done in a titration cell with three openings, kept immersed in a thermostated bath. The formation curves were plotted by taking value of (the degree of formation of metal-ligand complexes) against pH of the system. These plots indicate that these metal ions form 1:1 complexes with ABP. The results show that the pK1H values increases with an increase in temperature. The order of metal-ligand stability constants (log k1) has been found to be Cu2+ > Zn2+ > Cd2+ > Pb2+ > Sn2+ ≈ Hg2+ > Co2+ > Ni2+.
References (10)
- 1 Drug Discovery: A Historical Perspective [DOI]
- 2 The calculation of formation curves of metal complexes from pH titration curves in mixed solvents [DOI]
- 3 Stability of Chelate Compounds [DOI]
- 4 Formulation and Evaluation of Chitosan-Based Ampicillin Trihydrate Nanoparticles [DOI]
- 5 Metal ion interactions with drugs: Electrochemical study of complexation of various bivalent metal ions with nimesulide and ibuprofen [DOI]
- 6 Two-year toxicity and carcinogenicity studies of ampicillin trihydrate and penicillin VK in rodents [DOI]
- 7 Stability Constants of Some Biologically Important Pyrazoles and Their Ni2+ Complexes in Different Dielectric Constant of Medium [DOI]
- 8 Complexation reaction of metal ions with peptide systems. Part XIII. Stability constants and thermodynamic functions of praseodymium(III), neodymium(III) and samarium(III) with L-tyrosylglycylglycine and L-leucylglycylglycine [DOI]
- 9 Novel Organostannanes with Assorted Drugs: Synthesis, Spectral, and Potentiometric Studies [DOI]
- 10 The First Use of Penicillin in the United States [DOI]
Cited by 7
Irtiqa Ashraf Mir, Qurat Ul Ain, Tanzeela Qadir · Journal of Molecular Structure · 2024
Dipak Baral, Ajaya Bhattarai, Narendra Kumar Chaudhary · Ecotoxicology and Environmental Safety · 2024
Showing 2 of 7 known citations — external sources report more than can currently be individually listed.
Related research
- Factors Affecting the Use of Probiotics during Antibiotic Therapy — shares topic coverage
- Effect of Misuse of Antibiotics on Cytokine Patterns and Antibiogram of Bacteria Isolates from Surgical Site Infection in Benin City, Edo State, Nigeria — shares topic coverage
- Prevalence and Susceptibility Analysis of Carbapenem Resistant Gram-negative Pathogens in Super Specialty Tertiary Care Center, Mumbai, India — shares topic coverage
- Bacterial Aetiology and Antibiotic Susceptibility Profile of Post-Operative Sepsis among Surgical Patients in a Tertiary Hospital in Rural Eastern Uganda — shares topic coverage
- Characterization of the Genetic Supports for Betalactam Resistance in Escherichia coli Strains of Porcine Origin Producing Extended-spectrum Beta-Lactamase (ESBL) — shares topic coverage
Article metrics
Real usage data collected on this platform.
86
Page views
0
PDF downloads
40
Outbound clicks
7
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.