Skip to content
Research Article Open access CC BY 3.0

Solid State Characterization and Effect of PEG 20000 and Lecithin on Particle Size Reduction and Stability of Complexed Glibenclamide Nanocrystals

B. Sajeev Kumar, R. Saraswathi, K. Venkates Kumar, T. A. Sam, S. K Jha, S. A. Dhanaraj

Journal of Pharmaceutical Research International · pp. 1031–1044 · Published 28 Aug 2013

10.9734/BJPR/2013/5515

Abstract

Aims: To formulate and characterize GLB-PEG-LEC NCs (lecithin complexed Glibenclamide nanocrystals) and to analyze the effect of PEG 20000 and lecithin on drug properties, particle size reduction and stability of GLB NCs. Study Design: Precipitated (GLB-PEG) and complexed nanocrystals (GLB-PEG-LEC) of glibenclamide were characterized for particle size, size distribution, zeta potential and stability assessment using photon correlation spectroscopy. The crystallinity was analyzed by X-ray powder diffraction spectroscopy and differential scanning calorimetry. The chemical stability was assessed by means of infrared spectroscopy and surface morphology by scanning electron microscopy. Place and Duration of Study: Asian Institute of Medicine Science and Technology, Malaysia, between May 2102 and June 2013. Methodology: GLB-PEG NCs were prepared by precipitation technique using PEG 20000 and complexed by soybean lecithin. The effect of lecithin in particle size reduction, change in crystallinity, stability and surface properties of NCs were analyzed and compared with pure glibenclamide (GLB) and precipitated NCs. The formulations were optimized and its stability was assessed during a 3 month period. Results: Pure GLB exhibited an average particle size of 1551 nm. The average particle size of precipitated NCs was between 236 - 7000 nm, while that of complexed NCs was between 155 - 842 nm. The particle size of NC was found to decrease, whereas its zeta potential was found to increase after complexation. DSC studies showed no change in crystalline structure. PXRD studies proved that crystallinity was maintained in NCs. SEM analysis showed presence of spherical shape particles with a lipid coat on the surface after complexation. Stability studies revealed no change in particle size during 3 month period. FTIR studies showed the compatability of excipients with the drug. Conclusion: These results show that lecithin complexed GLB NCs could be utilized as promising carriers in development of various formulations due to its high stability and decreased particle size.

Nanocrystals complexation lecithin stability particle size precipitation

References (25)

  1. 1 Nanosuspensions in drug delivery [DOI]
  2. 2 Nanoparticles - A review [DOI]
  3. 3 Nanosuspensions as particulate drug formulations in therapy [DOI]
  4. 4 Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation [DOI]
  5. 5 Nanocrystal technology, drug delivery and clinical applications [DOI]
  6. 6 Nanonization strategies for poorly water-soluble drugs [DOI]
  7. 7 Drug nanocrystals for the formulation of poorly soluble drugs and its application as a potential drug delivery system [DOI]
  8. 8 Characterization of lipid nanoparticles by differential scanning calorimetry, X-ray and neutron scattering☆ [DOI]
  9. 9 New Aspects of Nanopharmaceutical Delivery Systems [DOI]
  10. 10 Preparation and evaluation of glibenclamide-polyglycolized glycerides solid dispersions with silicon dioxide by spray drying technique [DOI]
  11. 11 Physico-chemical parameters that govern nanoparticles fate also dictate rules for their molecular evolution [DOI]
  12. 12 Development and characterization of nanoparticles of glibenclamide by solvent displacement method.
  13. 13 Nanocrystals: Comparison of the size reduction effectiveness of a novel combinative method with conventional top-down approaches [DOI]
  14. 14 Diclofenac nanosuspensions: Influence of preparation procedure and crystal form on drug dissolution behaviour [DOI]
  15. 15 Particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs [DOI]
  16. 16 Regulatory perspective on the importance of ADME assessment of nanoscale material containing drugs [DOI]
  17. 17 Pharmacokinetic and pharmacodynamic studies of glibenclamide in non‐ insulin dependent diabetes mellitus. [DOI]
  18. 18 Lipid-based liquid crystalline nanoparticles as oral drug delivery vehicles for poorly water-soluble drugs: cellular interaction and in vivo absorption [DOI]
  19. 19 Effect of polyethylene glycol on preparation of rifampicin-loaded PLGA microspheres with membrane emulsification technique [DOI]
  20. 20 Stabilized amorphous glibenclamide nanoparticles by high-gravity technique [DOI]
  21. 21 Nanocrystals of Poorly Soluble Drugs for Oral Administration
  22. 22 Thermal degradation of amorphous glibenclamide [DOI]
  23. 23 In vitro and in vivo Evaluation of Glibenclamide using Surface Solid Dispersion (SSD) Approach
  24. 24 Physicochemical stability of phospholipid-dispersed suspensions of crystalline itraconazole [DOI]
  25. 25 Lipid-based liquid crystalline nanoparticles as oral drug delivery vehicles for poorly water-soluble drugs: cellular interaction and in vivo absorption

Cited by 3

Polymeric Stabilizers for Drug Nanocrystals

Leena Peltonen, Annika Tuomela, Jouni Hirvonen · Handbook of Polymers for Pharmaceutical Technologies · 2015

Showing 1 of 3 known citations — external sources report more than can currently be individually listed.

Article metrics

Real usage data collected on this platform.

14

Page views

0

PDF downloads

1

Outbound clicks

3

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.