Significance of Some Haemostasis Parameters in Type 2 Diabetic Patients in the Enugu State University of Science and Technology Teaching Hospital Enugu State Nigeria

Abstract

Diabetes mellitus has over the years become a public health challenge and a complex disease  characterized by chronic hyperglycemia that results in microvascular and macrovascular complications.  The present study was designed to determine alteration in haemostatic parameters in type 2 diabetic patients in Enugu State University of Science and Technology Teaching Hospital, Enugu State, Nigeria.  A total of 240 subjects comprising 120 Type 2 diabetic mellitus patients (T2DM )(60 males and 60 females) aged 20-55 years and 120 apparently healthy age and gender-matched controls were recruited for the study.  Blood samples five milliliters (5.0ml) was collected from subjects by veniipuncture for the determination of the haemostatic parameters.  The platelet count was determined using the Mindray 530 BC automated analyzer, Mindray, Japan, the PT, INR and APTT were determined by reagents purchased from Fortress Diagnostics, UK while the VWF antigen was determined with ELISA KIT purchased from Sulong Diagnostics, China. The result revealed an increase in platelet count (216.90 + 12.92 vs 208.60 + 9.43) and VWF (9.71 + 1.16 vs 7.30 + 0.42) in the T2DM patients compared to the non diabetic controls but this was not significant. This finding is suggestive of good clinical care and glycemic control for the patients.