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Research Article Open access CC BY 4.0

Short-term Effects of Garlic-Based Diets on mRNA Expression of Angiotensinogen, Angiotensin-1 Converting Enzyme, and Atrial Natriuretic Peptide in Cyclosporine-Induced Prehypertensive Rats

Oluwadamilare Oluwaseun Ajayi, Olubunmi Bolanle Ajayi

Annual Research & Review in Biology · pp. 32–42 · Published 4 Jul 2023

10.9734/arrb/2023/v38i530586

Abstract

The short-term effects of garlic, Allium sativum L., on the mRNA expression of angiotensin-1 converting enzyme (ACE), angiotensinogen (AGT), and atrial natriuretic peptide (ANP) in cyclosporine-induced prehypertensive rats were investigated in this work. Seven (7) groups of animals totaling n=7 were created. Prehypertensive (induced with 25mg/kg cyclosporine) and normal rats were given 10% and 20% diets based on garlic for 7 days. Alteration of Na+ and K+ levels, increased systolic and diastolic blood pressures, and ACE, AGT & ANP mRNA expressions were all associated with cyclosporin-induced prehypertension. In rats placed on garlic-based diets, these effects were reversed.

Hypertension cyclosporine garlic renin-angiotensin system

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Cited by 3

Garlic and Hypertension: Efficacy, Mechanism of Action, and Clinical Implications

Christopher Sleiman, Rose-Mary Daou, Antonio Al Hazzouri · Nutrients · 2024

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