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Research Article Open access CC BY 4.0

Severe Oligospermia Treatment with Testicular Sperm Using “ICSI”

Mustafa Zakaria, Aya Al-ibraheemi, Wassym Senhaji, Mohammed Ennaji, Noureddine Louanjli, Mohammed Zarqaoui

Annual Research & Review in Biology · pp. 37–44 · Published 4 Jun 2022

10.9734/arrb/2022/v37i630514

Abstract

Introduction: Assisted reproductive technology has been developed significantly throughout the past few years, particularly diagnosing and treating male infertility. Many studies have been performed showing that Intracytoplasmic Sperm Injection (ICSI) is a successful method to attain clinical pregnancy and live birth through impaired spermatozoa characteristics or low sperm count, such as severe oligospermia. Severe oligospermia indicates low sperm count, which in some cases leads to azoospermia. Severe oligospermia can be caused by several factors such as genetics or medication. In search of efficient treatment for couples with Severe oligospermia, numerous retrospective and prospective researches have reported high pregnancy and live birth rates through testicular sperm for men with severe oligospermia and cryptozoospermia with or without high sperm DNA damage. The research showed that the use of testicular sperm in combination with ICSI yielded a high pregnancy rate and live births over another source of sperm, such as ejaculated sperms. Moreover, the use of ICSI in severe oligospermia has shown successful fertilization and pregnancy. Methods: In search for effective treatment for couples with severe male factor, a number of small retrospective and prospective studies have reported high pregnancy and live birth rates using testicular sperm for men with necrozoospermia, cryptozoospermia and oligozoospermia with or without elevated sperm DNA damage. Although the data suggest that there may be some benefit in performing testicular sperm retrieval (TSR)-ICSI in select groups of non-azoospermic infertile men, there are potential risks involved with TSR. Clinicians should balance these risks prior to the recommendation of TSR-ICSI on the result of a semen analysis or sperm DNA test alone. Careful evaluation and management of male factor infertility is important. The use of TSR-ICSI in the absence of specific sperm DNA defects is still experimental. Discussion: In 1992 and subsequently, several reports indicated that ICSI was a successful technique to achieve clinical pregnancy and live birth using spermatozoa with severely impaired characteristics. The initial optimism over the ability of ICSI to overcome significant sperm abnormalities was later tempered by the findings of more recent publications suggesting that some sperm deficits may not be as effectively treated with ICSI. Conclusion: Severe oligospermia indicates low sperm count, which can lead to male infertility; severe oligospermia which can be overcome through ICSI. Genetic factors like microdeletions of the Y chromosome (Yq) can cause severe oligospermia or chemotherapy molecules, affecting the sperm count directly.

Severe oligospermia Medication and cancer treatment influence on oligozoospermia ICSI for men with sever oligozoospermia testicular sperm sperm retrieval ICSI male infertility sperm DNA

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Cited by 4

Gene Polymorphism, Microdeletion, and Gene Expression of PRM1, PRM2, AZFc in Infertile Males

Nashwa Jabbar Kadhum, Narges Dastmalchi, Parisa Banamolaei · Reports of Biochemistry and Molecular Biology · 2023

Polymorphisms and expression levels of TNP2, SYCP3, and AZFa genes in patients with azoospermia

Mohammad Ismael Ibrahim Jebur, Narges Dastmalchi, Parisa Banamolaei · Clinical and Experimental Reproductive Medicine · 2023

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