Serum Chemerin and Its Relationship with Cardiometabolic Risk Factors among Type 2 Diabetes Mellitus Patients

Abstract

Type 2 diabetes mellitus formerly known as adult-onset diabetes, is a heterogeneous group of disorders characterized by variable degrees of insulin resistance, impaired insulin secretion, and increased hepatic glucose production. The aim of this study is to measure cardiovascular disease risk factors (serum triglyceride, high-density lipoprotein, low-density lipoprotein, total cholesterol, Apo B100, fasting plasma glucose, and glycated hemoglobin) in patients with type 2 diabetes mellitus patients. To measure the serum levels of chemerin in patients with diabetes mellitus. To determine if there is any relationship between chemerin and CVD risk factors in patients with diabetes mellitus. Methodology: A total of one hundred (100) participants were studied consisting of fifty (50) diabetic and fifty (50) non-diabetics matched for age and sex, whose ages ranged from 41 to 60 years. Routine traditional lipid profile, fasting plasma glucose, Apo B100, HBA1C, and serum chemerin in both groups were assayed. The mean, SD, and correlation test were studied between the variables, and the test of significance of variables between the two groups was also analyzed using the statistical package of social sciences (SPSS). Result: In this study, the receiver operating characteristics (ROC) comparing the ability of serum chemerin to predict the presence of some traditional risk factors among diabetics, shows that serum chemerin is able to weakly predict the presences of Apo B100, triglycerides and waist hip ratio (WHR) (AUC= 0.666, P= 0.004) (AUC=0.604, P=0.755) and (AUC = 0.760, p= < 0.001) respectively. Conclusion: This study has been able to show some significant correlation between some of these traditionally recognized cardiovascular risk factors most especially Apolipoprotein B100, triglyceride and waist hip ratio and has been able to discriminate between the participants with diabetes mellitus and those who do not have the disease. It has also been able to suggest that chemerin might have a potential as a predictor of the presence of other cardiovascular risk factors among Nigerians with diabetes mellitus. However, further studies will be required to confirm these.