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Research Article Open access CC BY 4.0

Serum Aluminum Level and Its Relation with Parathyroid Hormone and Anemia in Children on Maintenance Hemodialysis

Amal A. Hegazy, Manal Abd El-Salam, Gamil El-Sayed Ibrahim

Journal of Advances in Medicine and Medical Research · pp. 494–502 · Published 27 Feb 2015

10.9734/BJMMR/2015/16146

Abstract

Aim: Renal excretion of aluminum is impaired in patients with chronic kidney disease, thereby increasing the risk of toxicity. Our aims were to determine the serum aluminum level in children on regular haemodialysis and to assess the effect of aluminum on PTH and blood parameters. Methodology: This is a case control study was done on 120 children, a group of 60 cases on regular hemodialysis, their ages ranged from 3 to 16 year. They were 27 males (45%) and 33 females (55%) they were selected from the hemodialysis unit and outpatient clinic of Al-Zahraa hospital, AL-Azhar University during the period from January 2014 to September 2014. The studied cases were divided into two groups according to the serum aluminum level; group A< 50 µg/L, and group B > 50 µg/L. Another group of 60 apparently healthy children with matched age and sex with the patient group served as a control. All subjects underwent thorough history taking, clinical examination and the following investigations: complete blood count, blood urea, serum creatinine, total serum calcium, serum phosphorus, serum aluminum, ferritin, PTH and aluminum level of drinking water and water for dialysis. Results: In this study serum aluminum level was significantly higher in cases compared with controls, it was (60±20 µg/L) and (20±10 µg/L) respectively (P=.000). Also we found serum PTH was significantly higher while serum calcium was significantly lower in cases compared to controls particularly in children whose aluminum >50 µg/L. We found a significant positive correlation between serum aluminum levels with PTH (r=.50, P=.001). Also our study reported that the aluminum level in both tap water (for drinking) and water from the dialysis unit their levels were 300 µg/L and 1 µg/L respectively. Conclusion: Drinking water is the main source of high aluminum level in our study and its overload is still a serious health problem in hemodialysis children. So aluminum should be diminished from drinking water to reach the permissible limit; routine monitoring of aluminum level and new modalities of hemodialysis is recommended.

Aluminum parathyroid hormone PTH hemodialysis children.

References (28)

  1. 1 Ferritin for the clinician [DOI]
  2. 2 Aluminum and Alzheimer's Disease: After a Century of Controversy, Is there a Plausible Link? [DOI]
  3. 3 2008 Japanese Society for Dialysis Therapy: Guidelines for Renal Anemia in Chronic Kidney Disease [DOI]
  4. 4 Cell Biology of Parathyroid Gland Hyperplasia in Chronic Renal Failure [DOI]
  5. 5 Aluminium content of foods and diets [DOI]
  6. 6 Pharmacoepidemiology of Anemia in Kidney Transplant Recipients [DOI]
  7. 7 Anemia in children with chronic kidney disease [DOI]
  8. 8 Aluminum, Alzheimer's disease and bone fragility [DOI]
  9. 9 Trace Metals' Abnormalities in Hemodialysis Patients: Relationship with Medications [DOI]
  10. 10 Frequency of Elevated Serum Aluminum Levels in Adult Dialysis Patients [DOI]
  11. 11 Impact of Hemodialysis Therapy on Anemia of Chronic Kidney Disease: The Potential Mechanisms [DOI]
  12. 12 The clinical impact of aluminium overload in renal failure [DOI]
  13. 13 Water Content of Aluminum, Dialysis Dementia, and Osteomalacia [DOI]
  14. 14 Long-Term Changes of Plasma Trace Element Concentrations in Chronic Hemodialysis Patients [DOI]
  15. 15 Epidemiology of anemia associated with chronic renal insufficiency [DOI]
  16. 16 Aluminum toxicity perturbs long bone calcification in the embryonic chick [DOI]
  17. 17 Trace elements in renal disease and hemodialysis [DOI]
  18. 18 Cytochemical Bioassay of Parathyroid Hormone [DOI]
  19. 19 Effect of aluminium load on parathyroid hormone synthesis [DOI]
  20. 20 Predictors of Erythropoietin Responsiveness in Chronic Hemodialysis Patients [DOI]
  21. 21 Inadvertent Aluminum Administration during Plasma Exchange Due to Aluminum Contamination of Albumin-Replacement Solutions [DOI]
  22. 22 Transferrin‐mediated uptake of aluminium by human parathyroid cells results in reduced parathyroid hormone secretion [DOI]
  23. 23 Trace elements in sera from patients with renal disease [DOI]
  24. 24 Effect of aluminium on calcium-sensing receptor expression, proliferation, and apoptosis of parathyroid glands from rats with chronic renal failure [DOI]
  25. 25 Anemia in Children with Chronic Kidney Disease [DOI]
  26. 26 Effect of Occupational Exposure to Aluminum on Parathyroid Hormone and Calcium Metabolism [DOI]
  27. 27 Aluminum Overload: An Easily-Ignored Problem in Dialysis Patients with Hyperparathyroidism [DOI]
  28. 28 [Influence of hemodialysis on changes of trace metals concentrations in blood of patients with end-stage renal failure].

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