Serotonin Syndrome after Initiation of Pregabalin on a Stable Regimen of Antidepressant Medication
Lena Jellestad, Lea Stocker, Josef Jenewein, Soenke Boettger
International Journal of Medical and Pharmaceutical Case Reports · pp. 1–4 · Published 23 Aug 2016
10.9734/IJMPCR/2016/28356Abstract
Aims: Serotonin syndrome is a potentially life-threatening drug interaction caused by excess serotonin concentration in the central nervous system and/or peripheral nervous system leading to cognitive, autonomic and somatic effects ranging from barely perceptible to fatal. A number of drugs and drug interactions cause serotonin syndrome, however, the exact mechanisms often remain elusive. Presentation of Case: In the following case, serotonin syndrome was caused by the addition of pregabalin in a patient with recurrent major depressive disorder and concurrent medication with paroxetine and trazodone. Discussion: This case illustrates the risk of polypsychopharmacology leading to an increased vulnerability towards serotonin syndrome. Conclusion: Pregabalin with its serotonergic action has a liability to cause serotonin syndrome. This should be especially kept in mind in patients with polypsychopharmacology.
Cited by 4
Matthew Gould, William D Harrison, Abbey Cahill-Kearns · BMJ Case Reports · 2021
Matthew Gunther, Jordan Broadway, Jose R Maldonado · Cureus · 2025
Edward Adi Pranoto, Aaron Bak Ong Wong · BMJ Supportive & Palliative Care · 2025
Sanjay Prakash, Chaturbhuj Rathore, Kaushik Rana · Seizure · 2021
Related research
- An Overview of Diabetic Neuropathy — shares topic coverage
- Method Development and Validation for the Simultaneous Estimation of Pregabalin, Methylcobalamin and Nortriptyline in Sustained Release Tablet Dosage Form Using UV-Spectrophotometry — shares topic coverage
- Evaluation of Antiparkinson Activity of Vitamin C, Tizanidine and Pregabalin against Haloperidol Induced Parkinsonism in Rats — shares topic coverage
- The Physiological and Pharmacological Roles of Melatonin and Pregabalin — shares topic coverage
- Clinicians' Perspectives on Pregabalin and Nortriptyline Combination Therapy for Neuropathic Pain in Indian Settings — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
4
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.