Ciclosporin Eye Drops in Ocular Graft-Versus-Host Disease: A Case Report
EL Filali El Mehdi, Farah Benelkadri, Houssaine Ait Lhaj, Mohamed Kriet, Fouad El Asri
Asian Journal of Research and Reports in Ophthalmology · pp. 102–106 · Published 29 Apr 2024
Abstract
Aims: To report a case of severe ocular graft-versus-host disease (GVHD) managed with topical ciclosporin. Introduction: Ocular graft-versus host disease is a rare and often misdiagnosed aetiology of dry eye syndrome. Case: We report a case of young women presenting with a severe and bilateral ocular surface inflammation with filamentous keratitis, posterior blepharitis, Meibomian gland dysfunction and neovascular invasion. Ocular GVHD was diagnosed due to severe dry eye symptoms and a history of allogeneic haematopoietic stem cell transplantation. Immunosuppressive treatment resulted in a spectacular anatomical and clinical improvement, rapid resolution of symptoms and improvement in visual acuity. Conclusion: Ocular GVHD should be considered in any severe dry eye syndrome associated with allogeneic bone marrow transplantation. Topical immunosuppressive therapies have revolutionised the curative management of these patients.
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